Growth hormone receptor binds JAK2

Stable Identifier
R-HSA-982792
Type
Reaction
Species
Homo sapiens
Compartment
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JAKs bind to the box1 motif (residues 297-305) of the Growth Hormone Receptor (GHR) (Argetsinger et al. 1993), a proline-rich region just inside the cell membrane. Binding is mediated largely by the JAK N-terminal FERM domain (Frank et al. 1995, He et al. 2003). JAK 2 binding enhances the stability of GHR (He et al. 2005).

Literature References
PubMed ID Title Journal Year
8343952 Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase

Witthuhn, BA, Carter-Su, C, Yang, X, Campbell, GS, Argetsinger, LS, Silvennoinen, O, Ihle, JN

Cell 1993
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