Metalloprotease cleavage of GHR

Stable Identifier
R-HSA-1168777
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Metalloprotease cleavage of GHR
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Approximately half of circulating GH is bound to Growth Hormone Binding Protein ((GHBP) Herington et al. 1986), a soluble fragment of the Growth Hormone Receptor (Baumann et al. 1986) formed when the extracellular region is proteolytically cleaved (Leung et al. 1987). This cleavage is mediated by metalloproteases such as TACE (ADAM17, Zhang et al. 2000). The membrane-bound remnant is subsequently degraded by the gamma-secretase complex (Cowan et al. 2005).
Participants
Input
Output
Participates
as an event of
Catalyst Activity

metalloendopeptidase activity of ADAM17 [plasma membrane]

Physical Entity
ADAM17 [plasma membrane] (Homo sapiens)
Activity
metalloendopeptidase activity (GO:0004222)
Inferred From
ADAM17 cleavage of Ghr (Mus musculus)
Authored
Jupe, S  (2010-10-14)
Reviewed
Herington, AC  (2011-06-13)
Waters, MJ  (2011-06-23)
Created
Jupe, S  (2011-01-07)
Cite Us!