Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence

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R-HSA-9825895
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Pathway
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Homo sapiens
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5/5
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Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence
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MITF target genes are involved in DNA replication, damage repair and chromosome maintenance and stability (Strub et al, 2011; Giuliano et al, 2010; Seoane et al, 2019; reviewed in Cheli et al, 2010; Goding and Arnheiter, 2019). Cells depleted of MITF through siRNA can undergo senescence as a result of accumulating DNA damage. In contrast, cells that are depleted of MITF by overexpression of ATF4 undergo reversible cell cycle arrest but do not undergo senescence, suggesting that ATF4 and translational reprogramming may block the senescence pathway (Giuliano et al, 2010; Falletta et al, 2017; reviewed in Goding and Arnheiter, 2019).
Literature References
PubMed ID Title Journal Year
30651597 Lineage-specific control of TFIIH by MITF determines transcriptional homeostasis and DNA repair

Seoane, M, Buhs, S, Iglesias, P, Strauss, J, Puller, AC, Müller, J, Gerull, H, Feldhaus, S, Alawi, M, Brandner, JM, Eggert, D, Du, J, Thomale, J, Wild, PJ, Zimmermann, M, Sternsdorf, T, Schumacher, U, Nollau, P, Fisher, DE, Horstmann, MA

Oncogene 2019
28096186 Translation reprogramming is an evolutionarily conserved driver of phenotypic plasticity and therapeutic resistance in melanoma

Falletta, P, Sánchez-Del-Campo, L, Chauhan, J, Effern, M, Kenyon, A, Kershaw, CJ, Siddaway, R, Lisle, R, Freter, R, Daniels, MJ, Lu, X, Tüting, T, Middleton, M, Buffa, FM, Willis, AE, Pavitt, G, Ronai, ZA, Sauka-Spengler, T, Hölzel, M, Goding, CR

Genes Dev 2017
21258399 Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma

Strub, T, Giuliano, S, Ye, T, Bonet, C, Keime, C, Kobi, D, Le Gras, S, Cormont, M, Ballotti, R, Bertolotto, C, Davidson, I

Oncogene 2011
19995375 Fifteen-year quest for microphthalmia-associated transcription factor target genes

Cheli, Y, Ohanna, M, Ballotti, R, Bertolotto, C

Pigment Cell Melanoma Res 2010
31123060 MITF-the first 25 years

Goding, CR, Arnheiter, H

Genes Dev 2019
20388797 Microphthalmia-associated transcription factor controls the DNA damage response and a lineage-specific senescence program in melanomas

Giuliano, S, Cheli, Y, Ohanna, M, Bonet, C, Beuret, L, Bille, K, Loubat, A, Hofman, V, Hofman, P, Ponzio, G, Bahadoran, P, Ballotti, R, Bertolotto, C

Cancer Res 2010
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Authored
Rothfels, K  (2023-01-26)
Reviewed
Arnheiter, H  (2024-02-26)
de la Serna, IL  (2024-05-21)
Vu, HN  (2024-11-05)
Steingrímsson, E  (2024-11-05)
Created
Rothfels, K  (2023-01-27)
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