MITF-M-dependent BRCA1 gene expression

Stable Identifier
R-HSA-9926521
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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MITF-M-dependent BRCA1 gene expression
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BRCA1 expression is regulated by the binding of MITF-M dimer to an E-box in intron 1, and silencing of MITF with siRNA abrogates expression of BRCA1 in human 501 Mel cells. (Strub et al, 2011; Beuret et al, 2011). BRCA1 expression may contribute to MITF-dependent suppression of DNA damage (Giuliano et al, 2010; reviewed in Goding and Arnheiter, 2019).
Literature References
PubMed ID Title Journal Year
21258399 Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma

Strub, T, Giuliano, S, Ye, T, Bonet, C, Keime, C, Kobi, D, Le Gras, S, Cormont, M, Ballotti, R, Bertolotto, C, Davidson, I

Oncogene 2011
31123060 MITF-the first 25 years

Goding, CR, Arnheiter, H

Genes Dev 2019
20388797 Microphthalmia-associated transcription factor controls the DNA damage response and a lineage-specific senescence program in melanomas

Giuliano, S, Cheli, Y, Ohanna, M, Bonet, C, Beuret, L, Bille, K, Loubat, A, Hofman, V, Hofman, P, Ponzio, G, Bahadoran, P, Ballotti, R, Bertolotto, C

Cancer Res 2010
21501420 BRCA1 is a new MITF target gene

Beuret, L, Ohanna, M, Strub, T, Allegra, M, Davidson, I, Bertolotto, C, Ballotti, R

Pigment Cell Melanoma Res 2011
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
MITF-M dimer:BRCA1 gene [nucleoplasm] (Homo sapiens)
Active Unit
MITF-M dimer [nucleoplasm]
Authored
Vu, HN  (2024-11-05)
Steingrímsson, E  (2024-11-05)
Reviewed
Vu, HN  (2024-11-05)
Steingrímsson, E  (2024-11-05)
Created
Rothfels, K  (2024-11-01)
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