MITF-M-dependent TERT expression

Stable Identifier
R-HSA-9858734
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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MITF-M-dependent TERT expression
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TERT encodes the telomerase responsible for maintenance of chromosome ends. TERT has been identified as a direct MITF target in melanoma cells by ChIP. Consistent with this, depletion of MITF causes a decrease in TERT mRNA by RNA seq and RT-qPCR (Strub et al, 2011). TERT is one of a number of potential MITF-dependent target genes involved in processes of DNA replication and damage repair (Strub et al, 2011; reviewed in Goding and Arnheiter, 2019)
Literature References
PubMed ID Title Journal Year
21258399 Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma

Strub, T, Giuliano, S, Ye, T, Bonet, C, Keime, C, Kobi, D, Le Gras, S, Cormont, M, Ballotti, R, Bertolotto, C, Davidson, I

Oncogene 2011
31123060 MITF-the first 25 years

Goding, CR, Arnheiter, H

Genes Dev 2019
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
MITF-M dimer:TERT gene [nucleoplasm] (Homo sapiens)
Active Unit
MITF-M dimer [nucleoplasm]
Authored
Rothfels, K  (2023-12-21)
Reviewed
Arnheiter, H  (2024-02-26)
de la Serna, IL  (2024-05-21)
Vu, HN  (2024-11-05)
Steingrímsson, E  (2024-11-05)
Created
Rothfels, K  (2024-01-14)
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