MITF-M-dependent MCM5 gene expression

Stable Identifier
R-HSA-9926532
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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MITF-M-dependent MCM5 gene expression
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Expression of MCM5, a component of the MCM2-7 replicative helicase complex, is regulated by binding of MITF-M to an E-box element in its promoter (Strub et al, 2011).
Literature References
PubMed ID Title Journal Year
21258399 Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma

Strub, T, Giuliano, S, Ye, T, Bonet, C, Keime, C, Kobi, D, Le Gras, S, Cormont, M, Ballotti, R, Bertolotto, C, Davidson, I

Oncogene 2011
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
MITF-M dimer:MCM5 gene [nucleoplasm] (Homo sapiens)
Active Unit
MITF dimer [nucleoplasm]
Authored
Vu, HN  (2024-11-05)
Steingrímsson, E  (2024-11-05)
Reviewed
Vu, HN  (2024-11-05)
Steingrímsson, E  (2024-11-05)
Created
Rothfels, K  (2024-11-01)
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