MITF-M dimer binds the TERT gene

Stable Identifier
R-HSA-9858721
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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TERT, encoding telomerase, is among the identified MITF-targets involved in processes of DNA replication, repair and damage response (Strub et al, 2011; reviewed in Goding and Arnheiter, 2019). MITF binds to E-box elements in the TERT promoter to upregulate its expression as assessed by ChIP in melanoma cells (Strub et al, 2011). Consistent with this, the TERT locus exhibits H3K4 methylation and RNA polymerase II occupancy, and MITF knockdown results in a decrease in TERT expression as assessed by RT-qPCR and RNA sequencing (Strub et al, 2011).
Literature References
PubMed ID Title Journal Year
21258399 Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma

Ye, T, Cormont, M, Keime, C, Kobi, D, Davidson, I, Le Gras, S, Giuliano, S, Bonet, C, Bertolotto, C, Ballotti, R, Strub, T

Oncogene 2011
31123060 MITF-the first 25 years

Arnheiter, H, Goding, CR

Genes Dev 2019
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