MITF-M binds the BRCA1 gene

Stable Identifier
R-HSA-9926487
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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MITF-M binds the BRCA1 gene
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MITF-M binds to E-box elements at position +182 of the BRCA1 gene as assessed by ChIP-seq in 501 melanoma cells (Strub et al, 2011, Beuret et al, 2011). Silencing of MITF with siRNA inhibits BRCA1 expression (Strub et al, 2011; Beuret et al, 2011). BRCA1 contributes to the MITF-dependent DNA damage and repair response (reviewed in Goding and Arnheiter, 2019).
Literature References
PubMed ID Title Journal Year
21258399 Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma

Strub, T, Giuliano, S, Ye, T, Bonet, C, Keime, C, Kobi, D, Le Gras, S, Cormont, M, Ballotti, R, Bertolotto, C, Davidson, I

Oncogene 2011
31123060 MITF-the first 25 years

Goding, CR, Arnheiter, H

Genes Dev 2019
21501420 BRCA1 is a new MITF target gene

Beuret, L, Ohanna, M, Strub, T, Allegra, M, Davidson, I, Bertolotto, C, Ballotti, R

Pigment Cell Melanoma Res 2011
Participants
Input
Output
Participates
as an event of
Authored
Vu, HN  (2024-11-05)
Steingrímsson, E  (2024-11-05)
Reviewed
Vu, HN  (2024-11-05)
Steingrímsson, E  (2024-11-05)
Created
Rothfels, K  (2024-11-01)
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