MITF-M dimer binds the LIG1 gene

Stable Identifier
R-HSA-9858713
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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MITF-M dimer binds the LIG1 gene
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MITF-dependent transcription has been implicated in processes of DNA replication and damage response (reviewed in Hou and Pavan, 2008; Cheli et al, 2010; Goding and Arnheiter, 2019). siRNA-depletion of MITF causes mitotic defects and the resulting accumulation of phosphorylated H2AX (gamma-H2AX) and TP53BP1 (also known as 53BP1) at sites of DNA damage (Giuliano et al, 2010; Strub et al, 2011). ChIP analysis in melanoma cells identifies a number of MITF target genes involved in the process of DNA replication and repair, including BRCA1, RAD53, RAD531L3, TERT and LIG1 (Strub et al, 2011). MITF binds to E-box elements in the promoter of the DNA ligase gene LIG1 to upregulate its expression. Consistent with this, the LIG gene shows enhanced H3K4 methylation and occupancy by RNA polymerase II (Strub et al, 2011).
Literature References
PubMed ID Title Journal Year
21258399 Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma

Ye, T, Cormont, M, Keime, C, Kobi, D, Davidson, I, Le Gras, S, Giuliano, S, Bonet, C, Bertolotto, C, Ballotti, R, Strub, T

Oncogene 2011
31123060 MITF-the first 25 years

Arnheiter, H, Goding, CR

Genes Dev 2019
20388797 Microphthalmia-associated transcription factor controls the DNA damage response and a lineage-specific senescence program in melanomas

Bertolotto, C, Giuliano, S, Hofman, V, Cheli, Y, Ohanna, M, Loubat, A, Hofman, P, Ponzio, G, Bille, K, Beuret, L, Bonet, C, Ballotti, R, Bahadoran, P

Cancer Res 2010
Participants
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Authored
Rothfels, K  (2023-12-21)
Reviewed
de la Serna, IL  (2024-05-21)
Arnheiter, H  (2024-02-26)
Steingrímsson, E  (2024-11-05)
Vu, HN  (2024-11-05)
Created
Rothfels, K  (2024-01-14)
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