MITF-M-dependent LIG1 expression

Stable Identifier
R-HSA-9858729
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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MITF-M-dependent LIG1 expression
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LIG1 encodes a DNA ligase involved in ligation of Okazaki fragments during DNA replication and repairing nicks in double-stranded DNA during DNA repair (Maffucci et al, 2018; reviewed in Howes and Tomkinson, 2012; Tomkinson et al, 2020). LIG1 was identified by ChIP as a direct MITF target in melanoma cells (Strub et al, 2011; reviewed in Goding and Arnheiter, 2019).
Literature References
PubMed ID Title Journal Year
22918593 DNA ligase I, the replicative DNA ligase

Howes, TR, Tomkinson, AE

Subcell Biochem 2012
21258399 Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma

Ye, T, Cormont, M, Keime, C, Kobi, D, Davidson, I, Le Gras, S, Giuliano, S, Bonet, C, Bertolotto, C, Ballotti, R, Strub, T

Oncogene 2011
31123060 MITF-the first 25 years

Arnheiter, H, Goding, CR

Genes Dev 2019
31630206 Altered DNA ligase activity in human disease

Khattri Bhandari, S, Naila, T, Tomkinson, AE

Mutagenesis 2020
30395541 Biallelic mutations in DNA ligase 1 underlie a spectrum of immune deficiencies

Ben-Omran, T, Cunningham-Rundles, C, Jurkiw, TJ, Boisson, B, Chavez, J, Cobat, A, Reynolds, PR, Maffucci, P, Radigan, L, Dinakar, C, Felgentreff, K, Ehlayel, M, Worth, A, Cortes, P, Abbott, JK, O'Brien, PJ, Notarangelo, LD, Gelfand, EW, Casanova, JL

J Clin Invest 2018
Participants
Input
Output
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as an event of
This event is regulated
Positively by
Regulator
MITF-M dimer:LIG1 gene [nucleoplasm] (Homo sapiens)
Active Unit
MITF-M dimer [nucleoplasm]
Authored
Rothfels, K  (2023-12-21)
Reviewed
de la Serna, IL  (2024-05-21)
Arnheiter, H  (2024-02-26)
Steingrímsson, E  (2024-11-05)
Vu, HN  (2024-11-05)
Created
Rothfels, K  (2024-01-14)
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