Reactome | SCN2B [plasma membrane]

SCN2B [plasma membrane]

Stable Identifier

R-HSA-197905

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Sodium channel beta-2 subunit, CIB2_HUMAN

Locations in the PathwayBrowser

Expand all

Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - L1CAM interactions (Homo sapiens)
      - Interaction between L1 and Ankyrins (Homo sapiens)
        
        Ankyrins link voltage-gated sodium and potassium channels to spectrin and L1 (Homo sapiens)
        
        KCNQ2,3, SCNAs:SCNBs [plasma membrane] (Homo sapiens)
        
        SCNAs:SCNBs [plasma membrane] (Homo sapiens)
        
        SCNBs [plasma membrane] (Homo sapiens)
        
        SCN2B [plasma membrane] (Homo sapiens)
        
        NFASC:NRCAM:ANK1-3:SPTA:SPTB:F-actin:KCNQ2,3, SCNAs:SCNBs [plasma membrane] (Homo sapiens)
        
        KCNQ2,3, SCNAs:SCNBs [plasma membrane] (Homo sapiens)
        
        SCNAs:SCNBs [plasma membrane] (Homo sapiens)
        
        SCNBs [plasma membrane] (Homo sapiens)
        
        SCN2B [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:O60939 SCN2B

Gene Names

SCN2B, UNQ326/PRO386

Chain

signal peptide:1-29, chain:30-215

Reference Genes

BioGPS Gene:6327 SCN2B

COSMIC (genes):SCN2B SCN2B

CTD Gene:6327 SCN2B

dbSNP Gene:6327 SCN2B

ENSEMBL:ENSG00000149575 SCN2B

HGNC:10589 SCN2B

KEGG:hsa:6327 SCN2B

Monarch:6327 SCN2B

NCBI Gene:6327 SCN2B

OMIM:601327 SCN2B

UCSC:O60939 SCN2B

Reference Transcript

RefSeq:NM_004588.5 SCN2B

Other Identifiers

11727611_a_at

11727612_at

11727613_at

11727614_at

11727615_x_at

16744960

210363_PM_s_at

210363_s_at

210364_PM_at

210364_at

235225_PM_at

235225_at

3393647

3393648

3393649

3393651

3393653

3393654

3393655

3393656

3393657

3393658

3393660

3393665

3393666

3393667

34918_at

50877_at

6327

7952011

A_23_P306819

A_32_P187571

A_33_P3394699

GE479829

GE54425

GE63295

GO:0001518

GO:0003012

GO:0005248

GO:0005886

GO:0006811

GO:0006814

GO:0007268

GO:0007399

GO:0009408

GO:0010467

GO:0010765

GO:0016020

GO:0017080

GO:0030315

GO:0030424

GO:0033268

GO:0034220

GO:0035725

GO:0042995

GO:0043194

GO:0045202

GO:0046684

GO:0048856

GO:0055085

GO:0060048

GO:0060371

GO:0061337

GO:0086002

GO:0086006

GO:0086010

GO:0086012

GO:0086091

GO:0098772

GO:0098915

GO:1902282

HMNXSV003025576

HMNXSV003028200

Hs.12714.0.S1_3p_at

Hs.12714.0.S1_3p_x_at

ILMN_1676998

PH_hs_0007603

PH_hs_0037120

TC11002343.hg

g5702193_3p_a_at

g6649596_3p_x_at

Participates

as a candidate of

Inferred To

SCN2B [plasma membrane] (Bos taurus)

Cross References

RefSeq

NP_004579.1

OpenTargets

ENSG00000149575

ENSEMBL

ENSP00000278947, ENST00000278947, ENSG00000149575

HPA

ENSG00000149575-SCN2B

GeneCards

SCN2B

PRO

O60939

Pharos - Targets

O60939

Orphanet

SCN2B

GlyGen

O60939

HMDB Protein

HMDBP09081

PDB

8S9C, 7XM9, 8G1A, 8S9B, 8I5Y, 7XMG, 7XMF, 8I5X, 5FDY, 7W9K, 7XVE, 7XVF, 6J8H, 6J8I, 7W9L, 6J8J, 8XMO, 7W9M, 8XMN, 8I5G, 7W9P, 8I5B, 7W77, 7W9T, 6J8G, 7W7F, 5FEB, 8THG, 6VRR, 8GZ1, 6J8E, 8THH, 8GZ2

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13535 ATR	1	ATR [nucleoplasm] (R-HSA-912443)	0.643	3
UniProt:Q63HN8 RNF213	3	RNF213(1-1172)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9715284) RNF213(1-1172)-ALK(1058-1620) fusion [cytosol] (R-HSA-9715291) RNF213 [cytosol] (R-HSA-9635613)	0.643	3
UniProt:O00471 EXOC5	2	EXOC5 [cytosol] (R-HSA-265045) EXOC5 [cytosol] (R-HSA-5623383)	0.643	3
UniProt:Q9H1U9 SLC25A51	1	SLC25A51 [mitochondrial inner membrane] (R-HSA-9938185)	0.643	3
UniProt:O43913 ORC5	1	ORC5 [nucleoplasm] (R-HSA-68516)	0.643	3
UniProt:O60443 GSDME	18	GSDME(1-270) [cytosol] (R-HSA-9647689) GSDME [cytosol] (R-HSA-9647620) GSDME (271-496) [cytosol] (R-HSA-9647615) GSDME(1-270) E177V [cytosol] (R-HSA-9710403) GSDME(1-270) T196M [cytosol] (R-HSA-9710429) GSDME(1-270) G17D [cytosol] (R-HSA-9710478) GSDME(1-270) E134A [cytosol] (R-HSA-9710410) GSDME(1-270) N24D [cytosol] (R-HSA-9710404) GSDME E210* [cytosol] (R-HSA-9710420) GSDME(1-270) I217N [cytosol] (R-HSA-9710437) GSDME(1-270) W44C [cytosol] (R-HSA-9710470) GSDME(1-270) P212L [cytosol] (R-HSA-9710487) GSDME(1-270) D14Y [cytosol] (R-HSA-9710450) GSDME(1-270) D18V [cytosol] (R-HSA-9710466) GSDME W46* [cytosol] (R-HSA-9711042) GSDME(1-270) I137T [cytosol] (R-HSA-9710473) GSDME(1-270) R48I [cytosol] (R-HSA-9710474) GSDME(1-270) G199E [cytosol] (R-HSA-9710427)	0.643	3
UniProt:P23468 PTPRD	1	PTPRD [plasma membrane] (R-HSA-6797868)	0.527	2
UniProt:Q96KP1 EXOC2	2	EXOC2 [plasma membrane] (R-HSA-264887) EXOC2 [cytosol] (R-HSA-5623376)	0.527	2
UniProt:Q99816 TSG101	2	TSG101 [endosome membrane] (R-HSA-2980549) TSG101 [cytosol] (R-HSA-917727)	0.527	2
UniProt:Q8IYI6 EXOC8	2	EXOC8 [plasma membrane] (R-HSA-264948) EXOC8 [cytosol] (R-HSA-5623388)	0.527	2
UniProt:Q9UPT5 EXOC7	2	EXOC7 [plasma membrane] (R-HSA-2872288) EXOC7 [cytosol] (R-HSA-5623386)	0.527	2
UniProt:Q13572 ITPK1	1	ITPK1 [cytosol] (R-HSA-994132)	0.527	2
UniProt:Q8WTW3 COG1	3	COG1 [trans-Golgi network membrane] (R-HSA-6813862) COG1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9921505) COG1 [Golgi membrane] (R-HSA-6808721)	0.527	2
UniProt:O60313 OPA1	3	OPA1 [mitochondrial inner membrane] (R-HSA-8867508) OPA1(88-194) [mitochondrial inner membrane] (R-HSA-8867509) OPA1(195-960) [mitochondrial inner membrane] (R-HSA-8867513)	0.527	2
UniProt:Q6YHU6 THADA	1	THADA [cytoplasm] (R-HSA-8870282)	0.527	2
UniProt:P56182 RRP1	1	RRP1 [nucleoplasm] (R-HSA-6792441)	0.527	2

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