Postmitotic nuclear pore complex (NPC) reformation

Stable Identifier
R-HSA-9615933
Type
Pathway
Species
Homo sapiens
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The NPC is reassembled during late anaphase/telophase when nascent nuclear membranes associate with the chromatin surfaces (reviewed by Wandke and Kutay 2013). Assembly of specific NPC proteins (nucleoporins) into the reforming NPC occurs in a temporally ordered fashion (reviewed by Otsuka and Ellenberg 2018). The GTPase RAN plays a central role in regulating NPC assembly during telophase, as well as earlier events in mitosis, such as mitotic spindle assembly (reviewed by Zierhut and Funabiki 2015). The active form of RAN (RAN:GTP), which is generated by the chromatin-associated RAN guanine nucleotide exchange factor RCC1, is converted to the inactive form (RAN:GDP) by the cytoplasmically localized RAN GTPase activating protein RANGAP1. During telophase, the elevated RAN:GTP near chromatin releases nucleoporins from complexes with nuclear transport receptors, including KPNB1/KPNA (importin alpha/beta) and TPNO1 (transportin), thereby liberating the nucleoporins for NPC assembly (reviewed by Forbes et al. 2015).

Literature References
PubMed ID Title Journal Year
29119545 Mechanisms of nuclear pore complex assembly - two different ways of building one molecular machine

Otsuka, S, Ellenberg, J

FEBS Lett. 2018
25982429 Nuclear transport factors: global regulation of mitosis

Forbes, DJ, Travesa, A, Nord, MS, Bernis, C

Curr. Opin. Cell Biol. 2015
23498932 Enclosing chromatin: reassembly of the nucleus after open mitosis

Wandke, C, Kutay, U

Cell 2013
26222742 Nucleosome functions in spindle assembly and nuclear envelope formation

Zierhut, C, Funabiki, H

Bioessays 2015
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