AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex

Stable Identifier
Homo sapiens
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Based on studies in human and Xenopus model systems (Rasala et al. 2006, Franz et al. 2007, Gillespie et al. 2007), and C. elegans (Fernandez and Piano 2006) model systems, the chromatin binding protein AHCTF1 (ELYS, MEL-28) selectively interacts with the Nup107-160 complex and acts as a seeding center for assembly of nuclear pore complexes (NPCs) at the chromatin surface in late anaphase/telophase. In the absence of AHCTF1, the nuclear envelope can re-assemble but lacks NPCs (Francz et al. 2007).

Literature References
PubMed ID Title Journal Year
17098863 ELYS is a dual nucleoporin/kinetochore protein required for nuclear pore assembly and proper cell division

Orjalo, AV, Briggs, S, Forbes, DJ, Rasala, BA, Shen, Z

Proc. Natl. Acad. Sci. U.S.A. 2006
17235358 MEL-28/ELYS is required for the recruitment of nucleoporins to chromatin and postmitotic nuclear pore complex assembly

Walczak, R, Galy, V, Antonin, W, Gentzel, M, Franz, C, Yavuz, S, Askjaer, P, Hetzer, M, Santarella, R, Mattaj, IW

EMBO Rep. 2007
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