Based on studies in human and Xenopus model systems (Rasala et al. 2006, Franz et al. 2007, Gillespie et al. 2007), and C. elegans (Fernandez and Piano 2006) model systems, the chromatin binding protein AHCTF1 (ELYS, MEL-28) selectively interacts with the Nup107-160 complex and acts as a seeding center for assembly of nuclear pore complexes (NPCs) at the chromatin surface in late anaphase/telophase. In the absence of AHCTF1, the nuclear envelope can re-assemble but lacks NPCs (Francz et al. 2007).
Orjalo, AV, Briggs, S, Forbes, DJ, Rasala, BA, Shen, Z
Walczak, R, Galy, V, Antonin, W, Gentzel, M, Franz, C, Yavuz, S, Askjaer, P, Hetzer, M, Santarella, R, Mattaj, IW
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