Reactome | AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex

AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex

Stable Identifier

R-HSA-9615901

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Metaphase and Anaphase (Homo sapiens)
      - Mitotic Anaphase (Homo sapiens)
        
        Nuclear Envelope (NE) Reassembly (Homo sapiens)
        
        Postmitotic nuclear pore complex (NPC) reformation (Homo sapiens)
        
        AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex (Homo sapiens)

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AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex

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Based on studies in human and Xenopus model systems (Rasala et al. 2006, Franz et al. 2007, Gillespie et al. 2007), and C. elegans (Fernandez and Piano 2006) model systems, the chromatin binding protein AHCTF1 (ELYS, MEL-28) selectively interacts with the Nup107-160 complex and acts as a seeding center for assembly of nuclear pore complexes (NPCs) at the chromatin surface in late anaphase/telophase. In the absence of AHCTF1, the nuclear envelope can re-assemble but lacks NPCs (Francz et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
17098863	ELYS is a dual nucleoporin/kinetochore protein required for nuclear pore assembly and proper cell division Orjalo, AV, Briggs, S, Forbes, DJ, Rasala, BA, Shen, Z	Proc. Natl. Acad. Sci. U.S.A.	2006
17235358	MEL-28/ELYS is required for the recruitment of nucleoporins to chromatin and postmitotic nuclear pore complex assembly Walczak, R, Galy, V, Antonin, W, Gentzel, M, Franz, C, Yavuz, S, Askjaer, P, Hetzer, M, Santarella, R, Mattaj, IW	EMBO Rep.	2007