After disassembly of the NPC in prophase, the Nup107-160 complex is sequestered through interaction with transportin (TPNO1) and/or importin-beta (KPNB1), as suggested by studies with Xenopus egg extracts and recombinant human proteins (Lau et al. 2009, Bernis et al. 2014), and in cultured human cells. Binding to TPNO1 and/or KPNB1 prevents Nup107-160 association with chromatin prior to the onset of NE reassembly.
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