Reactome | UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2

UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2

Stable Identifier

R-HSA-3000449

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nuclear envelope, nucleoplasm

Synonyms

Conjugation of SUMO1 to RANGAP1

ReviewStatus

5/5

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Metaphase and Anaphase (Homo sapiens)
      - Mitotic Anaphase (Homo sapiens)
        
        Nuclear Envelope (NE) Reassembly (Homo sapiens)
        
        Postmitotic nuclear pore complex (NPC) reformation (Homo sapiens)
        
        UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Homo sapiens)

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UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2

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The majority of RANGAP1 in the cell is conjugated with SUMO1 by the E3 ligase UBE2l (Ubc9) (Knipscheer et al. 1998, Lee et al. 1998). SUMO1 targets RANGAP1 to the nucleoporin RANBP2 (Mahajan et al. 1997).

Literature References

PubMed ID	Title	Journal	Year
18691969	Ubc9 sumoylation regulates SUMO target discrimination Sixma, TK, Fish, A, Olsen, JV, Klug, H, Pichler, A, Flotho, A, Johnson, ES, van Dijk, WJ, Mann, M, Knipscheer, P	Mol. Cell	2008
9019411	A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2 Guan, T, Gerace, L, Melchior, F, Mahajan, R, Delphin, C	Cell	1997
9497385	Modification of Ran GTPase-activating protein by the small ubiquitin-related modifier SUMO-1 requires Ubc9, an E2-type ubiquitin-conjugating enzyme homologue Tian, Q, Anderson, P, Matunis, MJ, Melchior, F, Mahajan, R, Lee, GW	J. Biol. Chem.	1998