RAN:GTP binds TNPO1/KPNB1 (transportin/importin beta) associated with the Nup107-160 complex and releases Nup107-160

Stable Identifier
R-HSA-9615945
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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RAN:GTP binds TNPO1/KPNB1 (transportin/importin beta) associated with the Nup107-160 complex and releases Nup107-160
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Based on studies with recombinant human proteins and Xenopus egg extracts, RAN:GTP binds to transportin (TNPO1) or importin beta (KPNB1) associated with the Nup107-160 complex (Lau et al. 2009), resulting in release of the latter.
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Inferred From
RAN:GTP binds transportin associated with Nup107-160 and displaces Nup107-160 (Homo sapiens)
RAN:GTP binds importin beta associated with nup107-160 and displaces nup107-160 (Xenopus laevis)
Authored
Gerace, L  (2019-11-07)
Created
Orlic-Milacic, M  (2018-08-09)
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