RCC1 stimulates GDP to GTP exchange on RAN

Stable Identifier
R-HSA-9624845
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Chromatin-associated RCC1 mediates GDP to GTP exchange on RAN, resulting in formation of the active RAN:GTP complex (Hetzer et al. 2000, reviewed by Zierhut and Funabiki 2015). The high concentration of RAN:GTP near chromatin promotes multiple aspects of nuclear envelope reassembly (reviewed by Forbes et al. 2015). RAN:GDP may be involved in recruitment of RCC1 to chromatin (Zhang et al. 2002).

Literature References
PubMed ID Title Journal Year
10911995 GTP hydrolysis by Ran is required for nuclear envelope assembly

Hetzer, M, Bilbao-Cort├ęs, D, Walther, TC, Gruss, OJ, Mattaj, IW

Mol. Cell 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
Ran guanyl-nucleotide exchange factor activity of RCC1 [chromosome]
Physical Entity
Activity
Orthologous Events
Authored
Created