Reactome | RCC1 stimulates GDP to GTP exchange on RAN

RCC1 stimulates GDP to GTP exchange on RAN

Stable Identifier

R-HSA-9624845

Type

Reaction [transition]

Species

Homo sapiens

Compartment

chromosome, cytosol

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Metaphase and Anaphase (Homo sapiens)
      - Mitotic Anaphase (Homo sapiens)
        
        Nuclear Envelope (NE) Reassembly (Homo sapiens)
        
        Postmitotic nuclear pore complex (NPC) reformation (Homo sapiens)
        
        RCC1 stimulates GDP to GTP exchange on RAN (Homo sapiens)

General

SBML | | PDF

SVG | | PPTX | SBGN

RCC1 stimulates GDP to GTP exchange on RAN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Chromatin-associated RCC1 mediates GDP to GTP exchange on RAN, resulting in formation of the active RAN:GTP complex (Hetzer et al. 2000, reviewed by Zierhut and Funabiki 2015). The high concentration of RAN:GTP near chromatin promotes multiple aspects of nuclear envelope reassembly (reviewed by Forbes et al. 2015). RAN:GDP may be involved in recruitment of RCC1 to chromatin (Zhang et al. 2002).

Literature References