Reactome | SYNE2 [nuclear envelope]

SYNE2 [nuclear envelope]

Stable Identifier

R-HSA-912404

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nuclear envelope

Synonyms

Nesprin-2, SYNE2_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q8WXH0 SYNE2

Gene Names

SYNE2, KIAA1011, NUA

Chain

chain:1-6885

Reference Genes

BioGPS Gene:23224 SYNE2

COSMIC - genes:SYNE2 SYNE2

CTD Gene:23224 SYNE2

dbSNP Gene:23224 SYNE2

ENSEMBL:ENSG00000054654 SYNE2

HGNC:17084 SYNE2

KEGG:hsa:23224 SYNE2

Monarch:23224 SYNE2

NCBI Gene:23224 SYNE2

OMIM:608442 SYNE2

UCSC:Q8WXH0 SYNE2

Reference Transcript

Participates

as a component of

Telomere Attachment Plate [nuclear envelope] (Homo sapiens)

as an input of

Telomeres cluster at the nuclear membrane (Homo sapiens)

Cross References

RefSeq

NP_878914.1, NP_878918.2, NP_878917.1, NP_055995.4

ENSEMBL

ENSP00000450831, ENST00000344113, ENST00000358025, ENSP00000344528, ENST00000458046, ENST00000555002, ENSP00000391937, ENSG00000054654, ENST00000341472, ENSP00000341781, ENSP00000350719

OpenTargets

ENSG00000054654

GeneCards

SYNE2

HPA

ENSG00000054654-SYNE2

PRO

Q8WXH0

Pharos - Targets

Q8WXH0

GlyGen

Q8WXH0

Orphanet

SYNE2

PDB

4DXS, 6XF1, 4FI9

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UH99 SUN2	1	SUN2 [nuclear envelope] (R-HSA-912382)	0.886	12
UniProt:Q9Y613 FHOD1			0.581	4
UniProt:Q9P0L0 VAPA	4	VAPA [endoplasmic reticulum membrane] (R-HSA-429677) VAPA [azurophil granule membrane] (R-HSA-6799364) VAPA [plasma membrane] (R-HSA-6806269) VAPA [cytosol] (R-HSA-9609920)	0.527	3
UniProt:Q15029 EFTUD2	1	EFTUD2 [nucleoplasm] (R-HSA-71883)	0.527	2
UniProt:Q9UKG1 APPL1	1	APPL1 [endosome membrane] (R-HSA-373630)	0.454	3

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