Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
ARHGEF12 [cytosol]
Stable Identifier
R-HSA-416560
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Rho guanine nucleotide exchange factor 12, ARHGC_HUMAN, LARG
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Semaphorin interactions (Homo sapiens)
Sema4D in semaphorin signaling (Homo sapiens)
Sema4D induced cell migration and growth-cone collapse (Homo sapiens)
Activation of Rho by LARG and PDZ-RhoGEF (Homo sapiens)
ARHGEF11,ARHGEF12 [cytosol] (Homo sapiens)
ARHGEF12 [cytosol] (Homo sapiens)
SEMA4D:ERBB2:p-Y-PLXNB1:RND1:ARHGEF11,ARHGEF12 [plasma membrane] (Homo sapiens)
ARHGEF11,ARHGEF12 [cytosol] (Homo sapiens)
ARHGEF12 [cytosol] (Homo sapiens)
LARG and PDZ-RhoGEF binds to Plexin-B1 (Homo sapiens)
ARHGEF11,ARHGEF12 [cytosol] (Homo sapiens)
ARHGEF12 [cytosol] (Homo sapiens)
SEMA4D:ERBB2:p-Y-PLXNB1:RND1:ARHGEF11,ARHGEF12 [plasma membrane] (Homo sapiens)
ARHGEF11,ARHGEF12 [cytosol] (Homo sapiens)
ARHGEF12 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
Cell death signalling via NRAGE, NRIF and NADE (Homo sapiens)
NRAGE signals death through JNK (Homo sapiens)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
ARHGEF12 [cytosol] (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (12/13) signalling events (Homo sapiens)
GEFs activate RhoA,B,C (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
ARHGEF12 [cytosol] (Homo sapiens)
LARG activation by G alpha 12/13 (Homo sapiens)
ARHGEF12 [cytosol] (Homo sapiens)
G-protein alpha (12/13):LARG [plasma membrane] (Homo sapiens)
ARHGEF12 [cytosol] (Homo sapiens)
LARG binds plexin B1 (Homo sapiens)
G-protein alpha (12/13):LARG [plasma membrane] (Homo sapiens)
ARHGEF12 [cytosol] (Homo sapiens)
G-protein alpha (12/13):LARG:Plexin B1 [plasma membrane] (Homo sapiens)
G-protein alpha (12/13):LARG [plasma membrane] (Homo sapiens)
ARHGEF12 [cytosol] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
CDC42 GTPase cycle (Homo sapiens)
CDC42 GEFs activate CDC42 (Homo sapiens)
CDC42 GEFs [cytosol] (Homo sapiens)
ARHGEF12 [cytosol] (Homo sapiens)
RHOA GTPase cycle (Homo sapiens)
RHOA GEFs activate RHOA (Homo sapiens)
RHOA GEFs [cytosol] (Homo sapiens)
ARHGEF12 [cytosol] (Homo sapiens)
RHOB GTPase cycle (Homo sapiens)
RHOB GEFs activate RHOB (Homo sapiens)
RHOB GEFs [cytosol] (Homo sapiens)
ARHGEF12 [cytosol] (Homo sapiens)
RHOC GTPase cycle (Homo sapiens)
RHOC GEFs activate RHOC (Homo sapiens)
RHOC GEFs [cytosol] (Homo sapiens)
ARHGEF12 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NZN5 ARHGEF12
Gene Names
ARHGEF12, KIAA0382, LARG
Chain
initiator methionine:1, chain:2-1544
Reference Genes
BioGPS Gene:23365 ARHGEF12
COSMIC (genes):ARHGEF12 ARHGEF12
CTD Gene:23365 ARHGEF12
dbSNP Gene:23365 ARHGEF12
ENSEMBL:ENSG00000196914.9 ARHGEF12
HGNC:14193 ARHGEF12
KEGG Gene (Homo sapiens):23365 ARHGEF12
Monarch:23365 ARHGEF12
NCBI Gene:23365 ARHGEF12
OMIM:604763 ARHGEF12
UCSC:Q9NZN5 ARHGEF12
Reference Transcript
RefSeq:XM_011542720.2 ARHGEF12
RefSeq:NM_001301084.1 ARHGEF12
RefSeq:XM_017017421.1 ARHGEF12
RefSeq:NM_015313.2 ARHGEF12
RefSeq:NM_001198665.1 ARHGEF12
Other Identifiers
0001770138
11731442_at
11731443_a_at
11731444_a_at
11750580_x_at
11762742_at
1555498_PM_at
1555498_at
16732428
201333_PM_s_at
201333_s_at
201334_PM_s_at
201334_s_at
201335_PM_s_at
201335_s_at
23365
3352502
3352504
3352505
3352506
3352507
3352508
3352533
3352535
3352539
3352540
3352544
3352548
3352549
3352551
3352553
3352555
3352558
3352559
3352560
3352561
3352563
3352564
3352566
3352568
3352569
3352570
3352572
3352573
3352574
3352577
3352579
3352581
3352582
3352583
3352585
3352586
3352587
3352588
3352590
3352592
3352593
3352595
3352596
3352597
3352599
3352600
3352601
3352603
3352605
3352606
3352607
3352608
3352609
3352610
3352611
3352615
3352616
3352617
35772_at
44179_at
7944560
7944601
AB002380_at
A_14_P117429
A_14_P131096
A_23_P127642
A_24_P175783
GE54946
GO:0001664
GO:0005085
GO:0005096
GO:0005515
GO:0005576
GO:0005615
GO:0005622
GO:0005737
GO:0005829
GO:0007186
GO:0007266
GO:0016020
GO:0023052
GO:0035556
GO:0043226
GO:0050790
GO:0051056
GO:0070062
GO:0098772
HMNXSV003038398
Hs.6582.0.A1_3p_a_at
Hs.6582.0.A2_3p_a_at
Hs2.374682.1.S1_3p_at
ILMN_1810712
PH_hs_0024933
TC11001102.hg
g7662087_3p_a_at
g7770232_RC_3p_a_at
Participates
as a member of
RHOA GEFs [cytosol] (Homo sapiens)
RHOC GEFs [cytosol] (Homo sapiens)
RHOB GEFs [cytosol] (Homo sapiens)
ARHGEF11,ARHGEF12 [cytosol] (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
as a candidate of
CDC42 GEFs [cytosol] (Homo sapiens)
as a component of
G-protein alpha (12/13):LARG [plasma membrane] (Homo sapiens)
as an input of
LARG activation by G alpha 12/13 (Homo sapiens)
Inferred To
RhoGEF2 [cytosol]
(Drosophila melanogaster)
rhgf-1 [cytosol]
(Caenorhabditis elegans)
arhgef12 [cytosol]
(Xenopus tropicalis)
ARHGEF12 [cytosol]
(Bos taurus)
ARHGEF12 [cytosol]
(Canis familiaris)
ARHGEF12 [cytosol]
(Danio rerio)
ARHGEF12 [cytosol]
(Gallus gallus)
ARHGEF12 [cytosol]
(Sus scrofa)
Arhgef12 [cytosol]
(Mus musculus)
Arhgef12 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
XP_011541022.1
,
XP_016872910.1
,
NP_001288013.1
,
NP_056128.1
,
NP_001185594.1
OpenTargets
ENSG00000196914
HPA
ENSG00000196914-ARHGEF12
GeneCards
Q9NZN5
Ensembl
ENSG00000196914
,
ENSP00000349056
,
ENST00000356641
,
ENST00000397843
,
ENSP00000380942
PRO
Q9NZN5
Pharos - Targets
Q9NZN5
PDB
1X86
,
1TXD
,
2OS6
,
2OMJ
HMDB Protein
HMDBP11507
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P08069 IGF1R
3
IGF1R(741-1367) [plasma membrane]
(R-HSA-2404180)
IGF1R(31-736) [plasma membrane]
(R-HSA-2404169)
p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane]
(R-HSA-2404172)
0.65
7
UniProt:P61586 RHOA
6
RHOA [secretory granule membrane]
(R-HSA-6804980)
RHOA [ficolin-1-rich granule membrane]
(R-HSA-6804971)
RHOA [endoplasmic reticulum membrane]
(R-HSA-5672082)
RHOA [cytosol]
(R-HSA-194866)
RHOA [cell junction]
(R-HSA-2134503)
RHOA [plasma membrane]
(R-HSA-194510)
0.609
2
UniProt:P61793
1
LPAR1 [plasma membrane]
(R-MMU-419354)
0.524
3
UniProt:Q9Q2G4 Q9Q2G4
0.462
2
© 2023
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text