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Ion transport by P-type ATPases
Stable Identifier
R-HSA-936837
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Transport of small molecules (Homo sapiens)
Ion channel transport (Homo sapiens)
Ion transport by P-type ATPases (Homo sapiens)
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The P-type ATPases (E1-E2 ATPases) are a large group of evolutionarily related ion pumps that are found in bacteria, archaea and eukaryotes. They are referred to as P-type ATPases because they catalyze auto-phosphorylation of a key conserved aspartate residue within the pump. They all appear to interconvert between at least two different conformations, E1 and E2. Most members of this transporter family pump a large variety of cations (Kuhlbrandt W, 2004).
Literature References
PubMed ID
Title
Journal
Year
15071553
Biology, structure and mechanism of P-type ATPases
Kühlbrandt, W
Nat Rev Mol Cell Biol
2004
Participants
Events
ATP7A transports cytosolic Cu2+ to extracellular region
(Homo sapiens)
ATP7B transports cytosolic Cu2+ to Golgi lumen
(Homo sapiens)
ATP2B1-4 transport cytosolic Ca2+ to extracellular region
(Homo sapiens)
ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen
(Homo sapiens)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen
(Homo sapiens)
ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen
(Homo sapiens)
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+
(Homo sapiens)
ATP1A:ATP1B:FXYD binds cardiac glycosides
(Homo sapiens)
ATP12A:ATP4B exchanges K+ for H+
(Homo sapiens)
ATP4A:ATP4B exchanges K+ for H+
(Homo sapiens)
ATP4A:ATP4B binds PPIs
(Homo sapiens)
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane
(Homo sapiens)
P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane
(Homo sapiens)
ATP13A4,5 transport divalent ions from extracellular region to cytosol
(Homo sapiens)
CUTC binds Cu+
(Homo sapiens)
ATP13A1 transports Mn2+ from cytosol to ER lumen
(Homo sapiens)
ATP13A2 transports cations from cytosol to lysosomal lumen
(Homo sapiens)
Participates
as an event of
Ion channel transport (Homo sapiens)
Event Information
Go Biological Process
monoatomic ion transmembrane transport (0034220)
Orthologous Events
Ion transport by P-type ATPases (Bos taurus)
Ion transport by P-type ATPases (Caenorhabditis elegans)
Ion transport by P-type ATPases (Canis familiaris)
Ion transport by P-type ATPases (Danio rerio)
Ion transport by P-type ATPases (Dictyostelium discoideum)
Ion transport by P-type ATPases (Drosophila melanogaster)
Ion transport by P-type ATPases (Gallus gallus)
Ion transport by P-type ATPases (Mus musculus)
Ion transport by P-type ATPases (Plasmodium falciparum)
Ion transport by P-type ATPases (Rattus norvegicus)
Ion transport by P-type ATPases (Saccharomyces cerevisiae)
Ion transport by P-type ATPases (Schizosaccharomyces pombe)
Ion transport by P-type ATPases (Sus scrofa)
Ion transport by P-type ATPases (Xenopus tropicalis)
Authored
Jassal, B (2010-08-24)
Reviewed
He, L (2010-11-15)
Created
Jassal, B (2010-08-24)
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