Reactome | CUTC binds Cu+

CUTC binds Cu+

Stable Identifier

R-HSA-5334788

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

A potential regulator of human copper metabolism has recently been described. Copper homeostasis protein cutC homolog (CutC) is a highly conserved cytosolic copper binding protein (Li et al. 2005, Li et al. 2010). Its function in human copper metabolism remains unclear but in C. elegans, the orthologous cutc1 protein down-regulation increases sensitivity to high levels of copper (Calafato et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
16182249	Identification and characterization of a novel Cut family cDNA that encodes human copper transporter protein CutC Li, J, Ji, C, Chen, J, Yang, Z, Wang, Y, Fei, X, Zheng, M, Gu, X, Wen, G, Xie, Y, Mao, Y	Biochem. Biophys. Res. Commun.	2005
19878721	Crystal structure of human copper homeostasis protein CutC reveals a potential copper-binding site Li, Y, Du, J, Zhang, P, Ding, J	J. Struct. Biol.	2010
18723824	Knock down of Caenorhabditis elegans cutc-1 exacerbates the sensitivity toward high levels of copper Calafato, S, Swain, S, Hughes, S, Kille, P, Stürzenbaum, SR	Toxicol. Sci.	2008