CUTC binds Cu+

Stable Identifier
Reaction [binding]
Homo sapiens
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A potential regulator of human copper metabolism has recently been described. Copper homeostasis protein cutC homolog (CutC) is a highly conserved cytosolic copper binding protein (Li et al. 2005, Li et al. 2010). Its function in human copper metabolism remains unclear but in C. elegans, the orthologous cutc1 protein down-regulation increases sensitivity to high levels of copper (Calafato et al. 2008).

Literature References
PubMed ID Title Journal Year
16182249 Identification and characterization of a novel Cut family cDNA that encodes human copper transporter protein CutC

Fei, X, Gu, X, Li, J, Xie, Y, Mao, Y, Zheng, M, Wang, Y, Ji, C, Chen, J, Yang, Z, Wen, G

Biochem. Biophys. Res. Commun. 2005
19878721 Crystal structure of human copper homeostasis protein CutC reveals a potential copper-binding site

Zhang, P, Du, J, Li, Y, Ding, J

J. Struct. Biol. 2010
18723824 Knock down of Caenorhabditis elegans cutc-1 exacerbates the sensitivity toward high levels of copper

St├╝rzenbaum, SR, Kille, P, Calafato, S, Swain, S, Hughes, S

Toxicol. Sci. 2008
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