Reactome | RIOK3 [cytosol]

RIOK3 [cytosol]

Stable Identifier

R-HSA-6791522

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Serine/threonine-protein kinase RIO3 ecNumber2.7.11.1/ecNumber, RIOK3_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O14730 RIOK3

Gene Names

RIOK3, SUDD

Chain

chain:1-519

Reference Genes

BioGPS Gene:8780 RIOK3

COSMIC (genes):RIOK3 RIOK3

CTD Gene:8780 RIOK3

dbSNP Gene:8780 RIOK3

ENSEMBL:ENSG00000101782 RIOK3

HGNC:11451 RIOK3

Monarch:8780 RIOK3

NCBI Gene:8780 RIOK3

OMIM:603579 RIOK3

UCSC:O14730 RIOK3

Reference Transcript

RefSeq:NM_003831.4 RIOK3

Other Identifiers

11725950_s_at

11725951_at

11747125_a_at

11749176_a_at

16851443

202129_PM_s_at

202129_s_at

202130_PM_at

202130_at

202131_3p_s_at

202131_PM_s_at

202131_s_at

32834_r_at

32835_at

3781674

3781675

3781676

3781677

3781682

3781683

3781684

3781685

3781686

3781687

3781688

3781689

3781690

3781691

3781693

3781695

3781696

3781698

3781701

3781702

3781703

3781704

3781705

3781706

3781707

3781709

3781710

3781711

3781712

3781713

79638_at

8020508

8780

A_14_P102167

A_23_P55578

A_23_P55584

A_33_P3317850

GE61134

GO:0002376

GO:0003824

GO:0004674

GO:0005515

GO:0005524

GO:0005737

GO:0005829

GO:0006468

GO:0007059

GO:0016740

GO:0030490

GO:0030688

GO:0031333

GO:0032728

GO:0039534

GO:0042254

GO:0043124

GO:0045087

GO:0045089

GO:0046872

GO:0051607

GO:0071359

GO:0089720

GO:0098542

GO:0098586

GO:0106310

GO:0140096

GO:1990786

HMNXSV003050325

Hs.209061.0.S1_3p_a_at

Hs.209061.0.S3_3p_at

ILMN_1724700

ILMN_1733747

ILMN_2404135

PH_hs_0012146

TC18000100.hg

g4507298_3p_a_at

g4507298_3p_x_at

Participates

as an output of

18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Homo sapiens)

as an input of

18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Homo sapiens)

Inferred To

riok3 [cytosol] (Danio rerio)

riok3 [cytosol] (Xenopus tropicalis)

Riok3 [cytosol] (Rattus norvegicus)

RIOK3 [cytosol] (Bos taurus)

RIOK3 [cytosol] (Caenorhabditis elegans)

RIOK3 [cytosol] (Canis familiaris)

RIOK3 [cytosol] (Gallus gallus)

RIOK3 [cytosol] (Mus musculus)

RIOK3 [cytosol] (Sus scrofa)

Dmel\CG3008 [cytosol] (Drosophila melanogaster)

Cross References

ZINC - World Drugs

RIOK3_HUMAN

Guide to Pharmacology - Targets

2188

ENSEMBL

ENST00000339486, ENSP00000341874, ENST00000577501, ENSP00000462548

OpenTargets

ENSG00000101782

ZINC - FDA approved

RIOK3_HUMAN

ZINC - Substances

RIOK3_HUMAN

ZINC - Biogenic

RIOK3_HUMAN

ZINC target

O14730

PRO

O14730

GlyGen

O14730

ZINC - Investigational

RIOK3_HUMAN

HPA

ENSG00000101782-RIOK3

Pharos - Targets

O14730

ZINC - Predictions - Purchasable

RIOK3_HUMAN

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92851 CASP10	4	CASP10(220-415) [cytosol] (R-HSA-933458) CASP10(1-219) [cytosol] (R-HSA-933454) CASP10(416-521) [cytosol] (R-HSA-933455) CASP10(1-521) [cytosol] (R-HSA-933453)	0.725	6
UniProt:Q14653 IRF3	6	IRF3 [cytosol] (R-HSA-166251) IRF3(2-271) [cytosol] (R-HSA-9729696) IRF3(272-427) [cytosol] (R-HSA-9729737) p-4S,T404-IRF3 [cytosol] (R-HSA-166258) p-4S,T404-IRF3 [nucleoplasm] (R-HSA-177654) p-5S,T404-IRF3 [nucleoplasm] (R-HSA-936418)	0.612	6
UniProt:Q92851-7 CASP10			0.544	3
UniProt:Q9BYX4 IFIH1	3	IFIH1 [cytosol] (R-HSA-913536) K48polyUb-IFIH1 [cytosol] (R-HSA-3080557) PolyUb-IFIH1 [cytosol] (R-HSA-6782812)	0.543	6
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.527	4
UniProt:P15880 RPS2	3	RPS2 [cytosol] (R-HSA-72347) Me2aR-RPS2 [cytosol] (R-HSA-8879138) RPS2 [nucleoplasm] (R-HSA-6790655)	0.527	2
UniProt:Q9UHD2 TBK1	5	p-S172-TBK1 [cytosol] (R-HSA-168379) TBK1 [cytosol] (R-HSA-166267) K63polyUb-K30,K401-TBK1 [cytosol] (R-HSA-9730430) p-TBK1 [cytosol] (R-HSA-9008705) pS-172,K48polyUb-TBK1 [cytosol] (R-HSA-3249397)	0.499	3