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LIFR [plasma membrane]
Stable Identifier
R-HSA-5693181
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Leukemia inhibitory factor receptor, LIFR_HUMAN
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 regulates transcription of genes involved in interleukin signaling (Homo sapiens)
LIFR gene expression (Homo sapiens)
LIFR [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-6 family signaling (Homo sapiens)
IL-6-type cytokine receptor ligand interactions (Homo sapiens)
CTF1 binds LIFR:JAKs (Homo sapiens)
CTF1:LIFR:JAKs [plasma membrane] (Homo sapiens)
JAKs:LIFR [plasma membrane] (Homo sapiens)
LIFR [plasma membrane] (Homo sapiens)
JAKs:LIFR [plasma membrane] (Homo sapiens)
LIFR [plasma membrane] (Homo sapiens)
JAKs bind LIFR (Homo sapiens)
JAKs:LIFR [plasma membrane] (Homo sapiens)
LIFR [plasma membrane] (Homo sapiens)
LIFR [plasma membrane] (Homo sapiens)
LIF binds LIFR (Homo sapiens)
JAKs:LIFR [plasma membrane] (Homo sapiens)
LIFR [plasma membrane] (Homo sapiens)
LIF:LIFR:JAKs [plasma membrane] (Homo sapiens)
JAKs:LIFR [plasma membrane] (Homo sapiens)
LIFR [plasma membrane] (Homo sapiens)
LIFR:JAKs bind gp130:JAKs:CNTFR (Homo sapiens)
CNTF:CNTFR,CRLF1:CLCF1:CNTFR:gp130:JAKs:LIFR:JAKs [plasma membrane] (Homo sapiens)
JAKs:LIFR [plasma membrane] (Homo sapiens)
LIFR [plasma membrane] (Homo sapiens)
JAKs:LIFR [plasma membrane] (Homo sapiens)
LIFR [plasma membrane] (Homo sapiens)
OSM binds LIFR:JAKs,OSMR:JAKs (Homo sapiens)
LIFR:JAKs,OSMR:JAKs [plasma membrane] (Homo sapiens)
JAKs:LIFR [plasma membrane] (Homo sapiens)
LIFR [plasma membrane] (Homo sapiens)
OSM:OSMR,LIFR [plasma membrane] (Homo sapiens)
LIFR:JAKs,OSMR:JAKs [plasma membrane] (Homo sapiens)
JAKs:LIFR [plasma membrane] (Homo sapiens)
LIFR [plasma membrane] (Homo sapiens)
OSM,LIF,CTF1 receptor complex binds gp130 (Homo sapiens)
LIF,OSM receptor complex:gp130 [plasma membrane] (Homo sapiens)
LIF,OSM,CTF1 receptor complex [plasma membrane] (Homo sapiens)
CTF1:LIFR:JAKs [plasma membrane] (Homo sapiens)
JAKs:LIFR [plasma membrane] (Homo sapiens)
LIFR [plasma membrane] (Homo sapiens)
LIF:LIFR:JAKs [plasma membrane] (Homo sapiens)
JAKs:LIFR [plasma membrane] (Homo sapiens)
LIFR [plasma membrane] (Homo sapiens)
OSM:OSMR,LIFR [plasma membrane] (Homo sapiens)
LIFR:JAKs,OSMR:JAKs [plasma membrane] (Homo sapiens)
JAKs:LIFR [plasma membrane] (Homo sapiens)
LIFR [plasma membrane] (Homo sapiens)
LIF,OSM,CTF1 receptor complex [plasma membrane] (Homo sapiens)
CTF1:LIFR:JAKs [plasma membrane] (Homo sapiens)
JAKs:LIFR [plasma membrane] (Homo sapiens)
LIFR [plasma membrane] (Homo sapiens)
LIF:LIFR:JAKs [plasma membrane] (Homo sapiens)
JAKs:LIFR [plasma membrane] (Homo sapiens)
LIFR [plasma membrane] (Homo sapiens)
OSM:OSMR,LIFR [plasma membrane] (Homo sapiens)
LIFR:JAKs,OSMR:JAKs [plasma membrane] (Homo sapiens)
JAKs:LIFR [plasma membrane] (Homo sapiens)
LIFR [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P42702 LIFR
Gene Names
LIFR
Chain
signal peptide:1-44, chain:45-1097
Reference Genes
BioGPS Gene:3977 LIFR
COSMIC (genes):LIFR LIFR
CTD Gene:3977 LIFR
dbSNP Gene:3977 LIFR
ENSEMBL:ENSG00000113594 LIFR
HGNC:6597 LIFR
KEGG:hsa:3977 LIFR
Monarch:3977 LIFR
NCBI Gene:3977 LIFR
OMIM:151443 LIFR
UCSC:P42702 LIFR
Reference Transcript
RefSeq:NM_001127671.1 LIFR
RefSeq:XM_011514040.2 LIFR
RefSeq:XM_017009463.1 LIFR
RefSeq:XM_011514042.2 LIFR
RefSeq:NM_002310.5 LIFR
Other Identifiers
11722685_s_at
11722686_a_at
11722687_a_at
11722688_a_at
11758145_s_at
16995500
16995534
205876_PM_at
205876_at
225571_PM_at
225571_at
225575_PM_at
225575_at
227771_PM_at
227771_at
229185_PM_at
229185_at
2854075
2854077
2854079
2854081
2854083
2854085
2854087
2854089
2854090
2854091
2854093
2854094
2854095
2854096
2854098
2854099
2854100
2854101
2854103
2854104
2854105
2854108
2854111
2854112
2854113
2854115
2854116
2854117
2854118
2854119
2854121
2854124
2854125
2854126
2854127
2854128
2854129
2854131
2854136
2854147
2854148
2854151
2854152
39617_at
3977
50408_at
56211_at
58445_at
59486_at
8111677
A_24_P325992
A_24_P397386
GE58283
GE59870
GO:0004896
GO:0004897
GO:0004923
GO:0004924
GO:0005127
GO:0005515
GO:0005576
GO:0005886
GO:0007166
GO:0008284
GO:0009897
GO:0016020
GO:0019221
GO:0019838
GO:0019955
GO:0034097
GO:0038165
GO:0043226
GO:0043235
GO:0048861
GO:0060089
GO:0070062
GO:0070120
HMNXSV003004441
HMNXSV003022692
HMNXSV003034176
Hs.124963.0.A1_3p_at
Hs.23767.1.A1_3p_at
Hs.23767.2.A1_3p_at
Hs.23767.2.A1_3p_x_at
Hs.23767.2.A2_3p_at
ILMN_1709094
PH_hs_0026101
S83362_s_at
TC05001289.hg
TC05001290.hg
U78628_at
X61615_at
g6042197_3p_at
p28609
Participates
as an output of
LIFR gene expression (Homo sapiens)
as an input of
JAKs bind LIFR (Homo sapiens)
as a component of
JAKs:LIFR [plasma membrane] (Homo sapiens)
Inferred To
lifr [plasma membrane]
(Xenopus tropicalis)
LIFR [plasma membrane]
(Bos taurus)
LIFR [plasma membrane]
(Canis familiaris)
LIFR [plasma membrane]
(Gallus gallus)
LIFR [plasma membrane]
(Sus scrofa)
lifra [plasma membrane]
(Danio rerio)
Lifr [plasma membrane]
(Mus musculus)
Lifr [plasma membrane]
(Rattus norvegicus)
Homologues of LIFR [plasma membrane]
(Canis familiaris)
Cross References
RefSeq
NP_001121143.1
,
NP_002301.1
,
XP_016864952.1
,
XP_011512344.1
,
XP_011512342.1
Guide to Pharmacology - Targets
1713
ENSEMBL
ENSP00000263409
,
ENST00000263409
,
ENST00000453190
,
ENSP00000398368
OpenTargets
ENSG00000113594
HPA
ENSG00000113594-LIFR
PRO
P42702
Pharos - Targets
P42702
GlyGen
P42702
Orphanet
LIFR
PDB
8D6A
,
8D74
,
8D7R
,
3E0G
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P26441 CNTF
1
CNTF [extracellular region]
(R-HSA-5696441)
0.747
9
UniProt:O95968 SG1D1
0.527
2
UniProt:P59665 DEFA1
9
DEFA1(20-94) [Golgi lumen]
(R-HSA-1467282)
DEFA1(66-94) [Golgi lumen]
(R-HSA-975663)
DEFA1(20-65) [Golgi lumen]
(R-HSA-8864970)
DEFA1(1-94) [Golgi lumen]
(R-HSA-1467215)
DEFA1(66-94) [extracellular region]
(R-HSA-1461998)
DEFA1(66-94) [azurophil granule lumen]
(R-HSA-1470038)
DEFA1(65-94) [extracellular region]
(R-HSA-1462022)
omega-N-(ADP-ribosyl)-L-arginine-DEFA1(65-94) [extracellular region]
(R-HSA-1972397)
DEFA1(65-94) [azurophil granule lumen]
(R-HSA-1470053)
0.527
2
UniProt:Q96LR4 TAFA4
0.527
2
UniProt:Q99523 SORT1
2
SORT1 [Golgi membrane]
(R-HSA-434332)
SORT1 [cytoplasmic vesicle membrane]
(R-HSA-434221)
0.506
3
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