Reactome | LIFR [plasma membrane]

LIFR [plasma membrane]

Stable Identifier

R-HSA-5693181

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Leukemia inhibitory factor receptor, LIFR_HUMAN

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX1 (Homo sapiens)
      - RUNX1 regulates transcription of genes involved in interleukin signaling (Homo sapiens)
        
        LIFR gene expression (Homo sapiens)
        
        LIFR [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P42702 LIFR

Gene Names

LIFR

Chain

signal peptide:1-44, chain:45-1097

Reference Genes

BioGPS Gene:3977 LIFR

COSMIC (genes):LIFR LIFR

CTD Gene:3977 LIFR

dbSNP Gene:3977 LIFR

ENSEMBL:ENSG00000113594 LIFR

HGNC:6597 LIFR

KEGG Gene (Homo sapiens):3977 LIFR

Monarch:3977 LIFR

NCBI Gene:3977 LIFR

OMIM:151443 LIFR

UCSC:P42702 LIFR

Reference Transcript

Other Identifiers

11722685_s_at

11722686_a_at

11722687_a_at

11722688_a_at

11758145_s_at

16995500

205876_PM_at

205876_at

225571_PM_at

225571_at

225575_PM_at

225575_at

227771_PM_at

227771_at

2854075

2854077

2854079

2854081

2854083

2854085

2854087

2854089

2854090

2854091

2854093

2854094

2854095

2854096

2854098

2854099

2854100

2854101

2854103

2854105

2854108

2854111

2854112

2854113

2854115

2854116

2854117

2854118

2854119

2854121

2854124

2854126

2854127

2854129

2854131

2854148

39617_at

3977

50408_at

56211_at

58445_at

8111677

A_24_P325992

A_24_P397386

GE58283

GE59870

GO:0003674

GO:0004896

GO:0004897

GO:0004923

GO:0004924

GO:0005127

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005886

GO:0005887

GO:0007165

GO:0007166

GO:0008150

GO:0008283

GO:0008284

GO:0009897

GO:0016020

GO:0016021

GO:0019221

GO:0019838

GO:0019955

GO:0032991

GO:0034097

GO:0038165

GO:0043226

GO:0043235

GO:0048861

GO:0070062

GO:0070120

HMNXSV003004441

HMNXSV003034176

Hs.23767.1.A1_3p_at

Hs.23767.2.A1_3p_at

Hs.23767.2.A1_3p_x_at

Hs.23767.2.A2_3p_at

ILMN_1709094

PH_hs_0026101

S83362_s_at

TC05001289.hg

X61615_at

g6042197_3p_at

Participates

as an output of

LIFR gene expression (Homo sapiens)

as an input of

JAKs bind LIFR (Homo sapiens)

as a component of

JAKs:LIFR [plasma membrane] (Homo sapiens)

Inferred To

lifrb [plasma membrane] (Danio rerio)

LIFR [plasma membrane] (Bos taurus)

LIFR [plasma membrane] (Canis familiaris)

LIFR [plasma membrane] (Gallus gallus)

LIFR [plasma membrane] (Sus scrofa)

lifra [plasma membrane] (Danio rerio)

Lifr [plasma membrane] (Mus musculus)

Lifr [plasma membrane] (Rattus norvegicus)

Homologues of LIFR [plasma membrane] (Danio rerio)

Cross References

RefSeq

XP_011512344.1, NP_002301.1, XP_016864952.1, NP_001121143.1, XP_011512342.1

Guide to Pharmacology - Targets

1713

OpenTargets

ENSG00000113594

HPA

ENSG00000113594-LIFR

GeneCards

P42702

Ensembl

ENSP00000263409, ENSP00000398368, ENST00000453190, ENST00000263409, ENSG00000113594

PRO

P42702

Pharos - Targets

P42702

Orphanet

16356

PDB

3E0G

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P26441 CNTF	1	CNTF [extracellular region] (R-HSA-5696441)	0.747	9
UniProt:Q99523 SORT1	2	SORT1 [cytoplasmic vesicle membrane] (R-HSA-434221) SORT1 [Golgi membrane] (R-HSA-434332)	0.506	3

Cite Us!