Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
LIF [extracellular region]
Stable Identifier
R-HSA-5696436
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Leukemia inhibitory factor, LIF_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-10 signaling (Homo sapiens)
IL10 negatively regulates extracellular inflammatory mediators (Homo sapiens)
IL10-downregulated extracellular proteins [extracellular region] (Homo sapiens)
LIF [extracellular region] (Homo sapiens)
Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
Expression of STAT3-upregulated extracellular proteins (Homo sapiens)
STAT3-upregulated extracellular proteins [extracellular region] (Homo sapiens)
LIF [extracellular region] (Homo sapiens)
Interleukin-6 family signaling (Homo sapiens)
IL-6-type cytokine receptor ligand interactions (Homo sapiens)
LIF binds LIFR (Homo sapiens)
LIF [extracellular region] (Homo sapiens)
LIF:LIFR:JAKs [plasma membrane] (Homo sapiens)
LIF [extracellular region] (Homo sapiens)
OSM,LIF,CTF1 receptor complex binds gp130 (Homo sapiens)
LIF,OSM receptor complex:gp130 [plasma membrane] (Homo sapiens)
LIF,OSM,CTF1 receptor complex [plasma membrane] (Homo sapiens)
LIF:LIFR:JAKs [plasma membrane] (Homo sapiens)
LIF [extracellular region] (Homo sapiens)
LIF,OSM,CTF1 receptor complex [plasma membrane] (Homo sapiens)
LIF:LIFR:JAKs [plasma membrane] (Homo sapiens)
LIF [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P15018 LIF
Gene Names
LIF, HILDA
Chain
signal peptide:1-22, chain:23-202
Reference Genes
BioGPS Gene:3976 LIF
COSMIC (genes):LIF LIF
CTD Gene:3976 LIF
dbSNP Gene:3976 LIF
ENSEMBL:ENSG00000128342 LIF
HGNC:6596 LIF
KEGG:hsa:3976 LIF
Monarch:3976 LIF
NCBI Gene:3976 LIF
OMIM:159540 LIF
UCSC:P15018 LIF
Reference Transcript
RefSeq:NM_002309.4 LIF
RefSeq:NM_001257135.1 LIF
Other Identifiers
11726497_at
11726498_at
11758619_s_at
16933760
205266_PM_at
205266_at
3957161
3957162
3957163
3957164
3957165
3957166
3957167
3957168
3957170
3957172
3976
441_s_at
8075310
A_24_P122137
A_24_P233488
GO:0000902
GO:0001666
GO:0001974
GO:0002376
GO:0005102
GO:0005125
GO:0005146
GO:0005515
GO:0005576
GO:0005615
GO:0005829
GO:0006355
GO:0006955
GO:0007566
GO:0008083
GO:0008283
GO:0008284
GO:0008285
GO:0010467
GO:0010628
GO:0010646
GO:0022414
GO:0023051
GO:0030154
GO:0030225
GO:0030324
GO:0033138
GO:0033141
GO:0033630
GO:0035019
GO:0042531
GO:0043410
GO:0045595
GO:0045651
GO:0045835
GO:0045944
GO:0046697
GO:0046888
GO:0048018
GO:0048144
GO:0048146
GO:0048286
GO:0048644
GO:0048666
GO:0048711
GO:0048856
GO:0048861
GO:0048863
GO:0050731
GO:0060135
GO:0060426
GO:0060463
GO:0060707
GO:0060708
GO:0070373
GO:0072108
GO:0072307
GO:0097696
GO:0098772
GO:0140013
HMNXSV003038722
ILMN_1738725
PH_hs_0030881
TC22000647.hg
X13967_at
g6006018_3p_at
Participates
as a member of
STAT3-upregulated extracellular proteins [extracellular region] (Homo sapiens)
IL10-downregulated extracellular proteins [extracellular region] (Homo sapiens)
as an input of
LIF binds LIFR (Homo sapiens)
as a component of
LIF:LIFR:JAKs [plasma membrane] (Homo sapiens)
Inferred To
LIF [extracellular region]
(Bos taurus)
LIF [extracellular region]
(Canis familiaris)
LIF [extracellular region]
(Sus scrofa)
Lif [extracellular region]
(Mus musculus)
Lif [extracellular region]
(Rattus norvegicus)
Cross References
RefSeq
NP_001244064.1
,
NP_002300.1
ENSEMBL
ENST00000403987
,
ENSP00000249075
,
ENST00000249075
,
ENSP00000384450
OpenTargets
ENSG00000128342
HPA
ENSG00000128342-LIF
PRO
P15018
Pharos - Targets
P15018
GlyGen
P15018
PDB
7N0A
,
8D6A
,
1EMR
,
1PVH
,
2Q7N
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P40189 IL6ST
2
p-Y-IL6ST [plasma membrane]
(R-HSA-8950439)
IL6ST [plasma membrane]
(R-HSA-448453)
0.623
2
UniProt:P61601 NCALD
1
NCALD [cytosol]
(R-HSA-450887)
0.556
3
UniProt:P60328 KRTAP12-3
1
KRTAP12-3 [cytosol]
(R-HSA-6810284)
0.556
3
UniProt:Q15323 KRT31
1
KRT31 [cytosol]
(R-HSA-6809616)
0.556
3
UniProt:O60760 HPGDS
1
HPGDS [cytosol]
(R-HSA-2142706)
0.556
3
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text