Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
OSM [extracellular region]
Stable Identifier
R-HSA-5696440
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Oncostatin-M, ONCM_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
Expression of STAT3-upregulated extracellular proteins (Homo sapiens)
STAT3-upregulated extracellular proteins [extracellular region] (Homo sapiens)
OSM [extracellular region] (Homo sapiens)
Interleukin-6 family signaling (Homo sapiens)
IL-6-type cytokine receptor ligand interactions (Homo sapiens)
OSM binds LIFR:JAKs,OSMR:JAKs (Homo sapiens)
OSM [extracellular region] (Homo sapiens)
OSM:OSMR,LIFR [plasma membrane] (Homo sapiens)
OSM [extracellular region] (Homo sapiens)
OSM,LIF,CTF1 receptor complex binds gp130 (Homo sapiens)
LIF,OSM receptor complex:gp130 [plasma membrane] (Homo sapiens)
LIF,OSM,CTF1 receptor complex [plasma membrane] (Homo sapiens)
OSM:OSMR,LIFR [plasma membrane] (Homo sapiens)
OSM [extracellular region] (Homo sapiens)
LIF,OSM,CTF1 receptor complex [plasma membrane] (Homo sapiens)
OSM:OSMR,LIFR [plasma membrane] (Homo sapiens)
OSM [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P13725 OSM
Gene Names
OSM
Chain
signal peptide:1-25, chain:26-221, propeptide:222-252
Reference Genes
BioGPS Gene:5008 OSM
COSMIC - genes:OSM OSM
CTD Gene:5008 OSM
dbSNP Gene:5008 OSM
ENSEMBL:ENSG00000099985 OSM
HGNC:8506 OSM
KEGG:hsa:5008 OSM
Monarch:5008 OSM
NCBI Gene:5008 OSM
OMIM:165095 OSM
UCSC:P13725 OSM
Reference Transcript
RefSeq:NM_020530.6 OSM
RefSeq:NM_001319108.1 OSM
Other Identifiers
11727756_at
11727757_at
1579_at
16933766
230170_PM_at
230170_at
3957189
3957190
3957191
3957192
3957193
3957195
5008
75007_at
8075316
A_23_P166408
A_33_P3277373
A_33_P3277378
GE80501
GO:0002376
GO:0002675
GO:0005102
GO:0005125
GO:0005147
GO:0005515
GO:0005576
GO:0005615
GO:0006355
GO:0006955
GO:0008083
GO:0008284
GO:0008285
GO:0010646
GO:0023051
GO:0032740
GO:0033138
GO:0038165
GO:0042531
GO:0043410
GO:0045944
GO:0046888
GO:0048018
GO:0050729
GO:0050731
GO:0051781
GO:0051897
GO:0098772
GO:1902036
HMNXSV003038776
Hs.134435.0.A1_3p_at
ILMN_1780546
M27288_at
PH_hs_0013169
TC22000648.hg
Participates
as a member of
STAT3-upregulated extracellular proteins [extracellular region] (Homo sapiens)
as an input of
OSM binds LIFR:JAKs,OSMR:JAKs (Homo sapiens)
as a component of
OSM:OSMR,LIFR [plasma membrane] (Homo sapiens)
Inferred To
OSM [extracellular region]
(Bos taurus)
OSM [extracellular region]
(Canis familiaris)
OSM [extracellular region]
(Sus scrofa)
Osm [extracellular region]
(Mus musculus)
Osm [extracellular region]
(Rattus norvegicus)
Cross References
RefSeq
NP_001306037.1
,
NP_065391.1
ENSEMBL
ENST00000215781
,
ENSG00000099985
,
ENSP00000215781
OpenTargets
ENSG00000099985
GeneCards
OSM
HPA
ENSG00000099985-OSM
PRO
P13725
Pharos - Targets
P13725
GlyGen
P13725
PDB
1EVS
,
8V29
,
8V2A
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P40189 IL6ST
2
IL6ST [plasma membrane]
(R-HSA-448453)
p-Y-IL6ST [plasma membrane]
(R-HSA-8950439)
0.759
5
UniProt:Q07021 C1QBP
3
C1QBP [cytosol]
(R-HSA-9645690)
C1QBP [mitochondrial matrix]
(R-HSA-9645697)
C1QBP [plasma membrane]
(R-HSA-158123)
0.527
3
UniProt:Q49AR2 CE022
0.527
3
UniProt:Q9C0C9 UBE2O
1
UBE2O [cytosol]
(R-HSA-947641)
0.527
2
UniProt:Q86VK4-3 ZNF410
0.488
2
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text