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IL6 [extracellular region]
Stable Identifier
R-HSA-447100
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Interleukin-6, IL6_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Senescence-Associated Secretory Phenotype (SASP) (Homo sapiens)
Regulation of IL6 transcription (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Leishmania parasite growth and survival (Homo sapiens)
Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
ADORA2B mediated anti-inflammatory cytokines production (Homo sapiens)
IL6 gene produces IL6 protein (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
CD163 mediating an anti-inflammatory response (Homo sapiens)
CD163 gene produces CD163 protein (Homo sapiens)
Glucocorticoid, IL6, IL10 [extracellular region] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by VENTX (Homo sapiens)
Regulation of IL6 transcription (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-10 signaling (Homo sapiens)
IL10 negatively regulates extracellular inflammatory mediators (Homo sapiens)
IL10-downregulated extracellular proteins [extracellular region] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
Expression of IL4,IL13-downregulated extracellular genes (Homo sapiens)
IL4,IL13-downregulated extracellular proteins [extracellular region] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
Expression of STAT3-upregulated extracellular proteins (Homo sapiens)
STAT3-upregulated extracellular proteins [extracellular region] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
Interleukin-6 family signaling (Homo sapiens)
Interleukin-6 signaling (Homo sapiens)
Assembly of hexameric IL-6 receptor (Homo sapiens)
IL6 receptor hexamer:JAKs [plasma membrane] (Homo sapiens)
IL6 receptor trimer:JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:IL6RB:JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
IL6:sIL6R:IL6RB:JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
IL6 receptor trimer:JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:IL6RB:JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
IL6:sIL6R:IL6RB:JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
IL6 binds IL6R (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
IL6 binds IL6R-2 (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
IL6:IL6RA:IL6RB:JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
IL6:IL6R-2 binds IL6ST-2 (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
IL6:IL6R-2:IL6ST-2 [extracellular region] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
IL6:IL6R-2:IL6ST-2 [extracellular region] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
IL6:sIL6R:IL6RB:JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
IL6ST is tyrosine phosphorylated (Homo sapiens)
IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6 receptor trimer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
IL6:sIL6R:IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
JAK activation (Homo sapiens)
IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6 receptor trimer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
IL6:sIL6R:IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
IL6 receptor hexamer:JAKs [plasma membrane] (Homo sapiens)
IL6 receptor trimer:JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:IL6RB:JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
IL6:sIL6R:IL6RB:JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
PTPN11 binds CBL (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11:CBL [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
PTPN11 binds p-Y759-IL6ST (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
PTPN11 is phosphorylated (Homo sapiens)
IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
Phosphorylated STATs are released (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
SOCS3 binds IL6ST (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
Serine phosphorylation of STATs (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine/serine phosphorylated STAT1/3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT1,STAT3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT1,STAT3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF-independent MAPK1/3 activation (Homo sapiens)
MAPK1 (ERK2) activation (Homo sapiens)
MAP2K2 binds MAPK1 (Homo sapiens)
IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
MAPK3 (ERK1) activation (Homo sapiens)
MAP2K1 binds MAPK3 (Homo sapiens)
IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P05231 IL6
Gene Names
IL6, IFNB2
Chain
signal peptide:1-29, chain:30-212
Reference Genes
BioGPS Gene:3569 IL6
COSMIC (genes):IL6 IL6
CTD Gene:3569 IL6
dbSNP Gene:3569 IL6
ENSEMBL:ENSG00000136244 IL6
HGNC:6018 IL6
KEGG:hsa:3569 IL6
Monarch:3569 IL6
NCBI Gene:3569 IL6
OMIM:147620 IL6
UCSC:P05231 IL6
Reference Transcript
RefSeq:NM_000600.4 IL6
RefSeq:XM_011515390.2 IL6
Other Identifiers
11746463_a_at
11760425_a_at
17044177
205207_PM_at
205207_at
2992587
2992588
2992592
2992593
2992594
2992595
2992596
2992597
2992598
2992599
2992600
2992601
2992602
3569
38299_at
8131803
A_14_P133151
A_23_P71037
A_33_P3407013
GE59660
GE84455
GO:0001781
GO:0002314
GO:0002376
GO:0002384
GO:0002446
GO:0002548
GO:0002639
GO:0002675
GO:0002690
GO:0005102
GO:0005125
GO:0005138
GO:0005515
GO:0005576
GO:0005615
GO:0005788
GO:0005896
GO:0006355
GO:0006953
GO:0006954
GO:0006955
GO:0006959
GO:0007165
GO:0008083
GO:0008284
GO:0008285
GO:0010573
GO:0010574
GO:0010575
GO:0010628
GO:0010718
GO:0010888
GO:0012501
GO:0014823
GO:0019221
GO:0030154
GO:0030168
GO:0031018
GO:0031175
GO:0032494
GO:0032682
GO:0032722
GO:0032731
GO:0032733
GO:0032740
GO:0032745
GO:0032755
GO:0032757
GO:0032760
GO:0032966
GO:0033138
GO:0035633
GO:0042102
GO:0042531
GO:0042593
GO:0042802
GO:0043065
GO:0043066
GO:0043410
GO:0045599
GO:0045669
GO:0045727
GO:0045765
GO:0045779
GO:0045893
GO:0045944
GO:0046427
GO:0048018
GO:0048661
GO:0048856
GO:0048870
GO:0050731
GO:0050768
GO:0050796
GO:0050829
GO:0050830
GO:0050871
GO:0051091
GO:0051240
GO:0051384
GO:0051607
GO:0060252
GO:0061470
GO:0061888
GO:0070050
GO:0070091
GO:0070092
GO:0070102
GO:0070301
GO:0071222
GO:0072540
GO:0072574
GO:0090091
GO:0090594
GO:0097421
GO:0097696
GO:0098542
GO:0098586
GO:0098772
GO:0150077
GO:0150078
GO:1900017
GO:1901731
GO:1902512
GO:1903978
GO:1904894
GO:1904996
GO:2000553
GO:2000635
GO:2000660
GO:2000676
HMNXSV003052866
HMNXSV003058441
ILMN_1699651
PH_hs_0026738
TC07000137.hg
X04602_s_at
Y00081_s_at
g10834983_3p_at
Participates
as a member of
IL4,IL13-downregulated extracellular proteins [extracellular region] (Homo sapiens)
STAT3-upregulated extracellular proteins [extracellular region] (Homo sapiens)
IL10-downregulated extracellular proteins [extracellular region] (Homo sapiens)
Glucocorticoid, IL6, IL10 [extracellular region] (Homo sapiens)
as an output of
IL6 gene produces IL6 protein (Homo sapiens)
Regulation of IL6 transcription (Homo sapiens)
as an input of
IL6 binds IL6R (Homo sapiens)
IL6 binds IL6R-2 (Homo sapiens)
as a component of
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
Other forms of this molecule
IL6 [endoplasmic reticulum lumen]
p-IL6 [endoplasmic reticulum lumen]
Inferred To
Il6 [extracellular region]
(Mus musculus)
Il6 [extracellular region]
(Rattus norvegicus)
il6 [extracellular region]
(Danio rerio)
il6 [extracellular region]
(Xenopus tropicalis)
IL6 [extracellular region]
(Bos taurus)
IL6 [extracellular region]
(Canis familiaris)
IL6 [extracellular region]
(Gallus gallus)
IL6 [extracellular region]
(Sus scrofa)
Cross References
RefSeq
NP_000591.1
,
XP_011513692.1
OpenTargets
ENSG00000136244
ENSEMBL
ENSP00000385675
,
ENSP00000258743
,
ENST00000258743
,
ENST00000404625
HPA
ENSG00000136244-IL6
PRO
P05231
Pharos - Targets
P05231
Orphanet
IL6
GlyGen
P05231
PDB
4J4L
,
1ALU
,
5FUC
,
1P9M
,
8QY6
,
4O9H
,
4ZS7
,
8QY5
,
7NXZ
,
8D82
,
4NI7
,
1IL6
,
2IL6
,
4CNI
,
4NI9
HMDB Protein
HMDBP02087
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P08887 IL6R
1
IL6R [plasma membrane]
(R-HSA-197824)
0.823
7
UniProt:P40189 IL6ST
2
p-Y-IL6ST [plasma membrane]
(R-HSA-8950439)
IL6ST [plasma membrane]
(R-HSA-448453)
0.667
3
UniProt:P08887-PRO_0000450730 IL6R
0.602
3
UniProt:Q92673 SORL1
2
SORL1 [endosome membrane]
(R-HSA-8871475)
SORL1 [Golgi membrane]
(R-HSA-8871510)
0.571
4
UniProt:Q99523 SORT1
2
SORT1 [Golgi membrane]
(R-HSA-434332)
SORT1 [cytoplasmic vesicle membrane]
(R-HSA-434221)
0.571
4
UniProt:P05231 IL6
3
IL6 [extracellular region]
(R-HSA-447100)
IL6 [endoplasmic reticulum lumen]
(R-HSA-8956764)
p-IL6 [endoplasmic reticulum lumen]
(R-HSA-8957044)
0.558
2
UniProt:Q05516 ZBTB16
1
ZBTB16 [cytosol]
(R-HSA-976047)
0.519
2
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