Reactome | TFAP2A [nucleoplasm]

TFAP2A [nucleoplasm]

Stable Identifier

R-HSA-8864280

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Transcription factor AP-2-alpha, AP2-alpha, AP-2, AP2TF, Activator protein 2

Locations in the PathwayBrowser for interactor UniProt:Q09472 EP300

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External Reference Information

External Reference

UniProt:P05549 TFAP2A

Gene Names

TFAP2A, AP2TF, TFAP2

Chain

chain:1-437

Reference Genes

BioGPS Gene:7020 TFAP2A

COSMIC - genes:TFAP2A TFAP2A

CTD Gene:7020 TFAP2A

dbSNP Gene:7020 TFAP2A

ENSEMBL:ENSG00000137203 TFAP2A

HGNC:11742 TFAP2A

KEGG:hsa:7020 TFAP2A

Monarch:7020 TFAP2A

NCBI Gene:7020 TFAP2A

OMIM:107580 TFAP2A

UCSC:P05549 TFAP2A

Reference Transcript

Participates

as a protein marker of

embryonic non-neural surface ectoderm cell (Homo sapiens)

as an input of

as a component of

as an output of

Expression of TFAP2A in the neural plate border (Homo sapiens)

as a member of

This entity regulates

Positively

Expression of ZIC1 in the neural plate border (Homo sapiens)

Inferred To

aptf-2 [nucleoplasm] (Caenorhabditis elegans)

tfap2a [nucleoplasm] (Xenopus tropicalis)

aptf-1 [nucleoplasm] (Caenorhabditis elegans)

TfAP-2 [nucleoplasm] (Drosophila melanogaster)

Tfap2a [nucleoplasm] (Mus musculus)

Tfap2a [nucleoplasm] (Rattus norvegicus)

TFAP2A [nucleoplasm] (Bos taurus)

TFAP2A [nucleoplasm] (Canis familiaris)

TFAP2A [nucleoplasm] (Gallus gallus)

TFAP2A [nucleoplasm] (Sus scrofa)

aptf-4 [nucleoplasm] (Caenorhabditis elegans)

Homologues of TFAP2A [nucleoplasm] (Caenorhabditis elegans)

aptf-3 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001027451.1, NP_001035890.1

ENSEMBL

ENSG00000137203, ENST00000319516, ENSP00000316516, ENSP00000368928, ENST00000379608

OpenTargets

ENSG00000137203

GeneCards

TFAP2A

HPA

ENSG00000137203-TFAP2A

PRO

P05549

Pharos - Targets

P05549

GlyGen

P05549

Orphanet

TFAP2A

PDB

8J0K, 8J0L, 8J0R

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9H4Y5 GSTO2	1	GSTO2 [cytosol] (R-HSA-176066)	0.666	4
UniProt:P63279 UBE2I	9	monoSUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) UBE2I [nuclear envelope] (R-HSA-4655408) SUMO3-C93-UBE2I [nucleoplasm] (R-HSA-3730629) UBE2I [nucleoplasm] (R-HSA-912481) SUMO1-C93-UBE2I [nucleoplasm] (R-HSA-3730617) SUMO2-C93-UBE2I [nucleoplasm] (R-HSA-3730619) SUMO1-C93-UBE2I [cytosol] (R-HSA-4656909) UBE2I [cytosol] (R-HSA-4655342) SUMO2-C93-UBE2I [cytosol] (R-HSA-4656944)	0.646	4
UniProt:P06748 NPM1	11	NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [granular component] (R-HSA-9017702) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.591	6
UniProt:Q86TX2 ACOT1	1	ACOT1 [cytosol] (R-HSA-2066771)	0.564	2
UniProt:Q13064 MKRN3			0.556	3
UniProt:P06429 VE7			0.553	2
UniProt:Q09472 EP300	5	EP300 [nucleoplasm] (R-HSA-381325) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) monoSUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306)	0.508	7
UniProt:P61244 MAX	1	MAX [nucleoplasm] (R-HSA-3006627)	0.499	2

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