Expression of ZIC1 in the neural plate border

Stable Identifier
R-HSA-9835244
Type
Reaction [uncertain]
Species
Homo sapiens
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5/5
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Stimulation of WNT signaling in human embryonic stem cells induces the expression of ZIC1 and the differentiation of multipotent neural crest-like cells (Leung et al. 2016). ZIC1 and TFAP2A are induced days later than early markers of neural border such as GBX2 (Leung et al. 2016). SOX2 and POU5F1 (OCT4), which may interact with TFAP2A, bind downstream of the ZIC1 coding region (inferred from chicken homologs in Hovland et al. 2022). In Xenopus, Zic1 is expressed in prospective neuroectoderm at the beginning of gastrulation and acts to induce neural fate (Mizuseki et al. 1998).
Literature References
PubMed ID Title Journal Year
26839343 WNT/β-catenin signaling mediates human neural crest induction via a pre-neural border intermediate

Prasad, MS, Murdoch, B, Gomez, GA, Salem, AF, García-Castro, MI, Leung, AW

Development 2016
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