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Expression of ZIC1 in the neural plate border
Stable Identifier
R-HSA-9835244
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Developmental Biology (Homo sapiens)
Gastrulation (Homo sapiens)
Specification of the neural plate border (Homo sapiens)
Expression of ZIC1 in the neural plate border (Homo sapiens)
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Stimulation of WNT signaling in human embryonic stem cells induces the expression of ZIC1 and the differentiation of multipotent neural crest-like cells (Leung et al. 2016). ZIC1 and TFAP2A are induced days later than early markers of neural border such as GBX2 (Leung et al. 2016). SOX2 and POU5F1 (OCT4), which may interact with TFAP2A, bind downstream of the ZIC1 coding region (inferred from chicken homologs in Hovland et al. 2022). In Xenopus, Zic1 is expressed in prospective neuroectoderm at the beginning of gastrulation and acts to induce neural fate (Mizuseki et al. 1998).
Literature References
PubMed ID
Title
Journal
Year
26839343
WNT/β-catenin signaling mediates human neural crest induction via a pre-neural border intermediate
Prasad, MS
,
Murdoch, B
,
Gomez, GA
,
Salem, AF
,
García-Castro, MI
,
Leung, AW
Development
2016
Participants
Input
ZIC1 gene [nucleoplasm]
(Homo sapiens)
Output
ZIC1 [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Specification of the neural plate border (Homo sapiens)
This event is regulated
Positively by
Regulator
POU5F1:SOX2:ZIC1 gene [nucleoplasm]
(Homo sapiens)
Active Unit
POU5F1 [nucleoplasm]
SOX2 [nucleoplasm]
Regulator
WNT3A [extracellular region]
(Homo sapiens)
Regulator
TFAP2A [nucleoplasm]
(Homo sapiens)
Inferred From
Expression of ZIC1 in the neural plate border (Gallus gallus)
Authored
May, B (2023-05-10)
Reviewed
Patthey, C (2023-10-28)
Gunhaga, L (2023-10-28)
Created
May, B (2023-05-12)
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