Reactome | TIMP3 [platelet dense granule lumen]

TIMP3 [platelet dense granule lumen]

Stable Identifier

R-HSA-8848904

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

platelet dense granule lumen

Synonyms

Metalloproteinase inhibitor 3, TIMP3_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P35625 TIMP3

Gene Names

TIMP3

Chain

signal peptide:1-23, chain:24-211

Reference Genes

BioGPS Gene:7078 TIMP3

COSMIC (genes):TIMP3 TIMP3

CTD Gene:7078 TIMP3

dbSNP Gene:7078 TIMP3

ENSEMBL:ENSG00000100234 TIMP3

ENSEMBL_homo_sapiens_GENE:ENSG00000100234.12 TIMP3

HGNC:11822 TIMP3

KEGG Gene (Homo sapiens):7078 TIMP3

Monarch:7078 TIMP3

NCBI Gene:7078 TIMP3

OMIM:188826 TIMP3

UCSC:P35625 TIMP3

Reference Transcript

RefSeq:NM_000362.4 TIMP3

Other Identifiers

1034_at

1035_g_at

11715435_s_at

11715436_at

11715437_at

16929442

201147_PM_s_at

201147_s_at

201148_PM_s_at

201148_s_at

201149_PM_s_at

201149_s_at

201150_PM_s_at

201150_s_at

3943506

3943507

3943508

3943533

3943537

3943538

3943540

3943541

3943542

3943543

3943556

7078

8072626

A_23_P399078

D45917_s_at

GE78973

GO:0002020

GO:0004857

GO:0005515

GO:0005576

GO:0005604

GO:0005615

GO:0005634

GO:0007601

GO:0008191

GO:0009725

GO:0030163

GO:0030312

GO:0030414

GO:0031012

GO:0031089

GO:0031410

GO:0034097

GO:0043226

GO:0046872

GO:0050877

GO:0050896

GO:0051045

GO:0062023

GO:0071310

GO:0098772

GO:1904684

HMNXSV003005589

Hs.245188.0.A2_3p_a_at

Hs.245188.0.A3_3p_a_at

ILMN_1701461

PH_hs_0013028

TC22000248.hg

U14394_at

g1519557_3p_a_at

g9257248_3p_a_at

Participates

as a member of

Platelet dense granule content [platelet dense granule lumen] (Homo sapiens)

Other forms of this molecule

TIMP3 [extracellular region]

Inferred To

Homologues of TIMP3 [platelet dense granule lumen] (Caenorhabditis elegans)

TIMP3 [platelet dense granule lumen] (Bos taurus)

TIMP3 [platelet dense granule lumen] (Caenorhabditis elegans)

TIMP3 [platelet dense granule lumen] (Canis familiaris)

TIMP3 [platelet dense granule lumen] (Drosophila melanogaster)

TIMP3 [platelet dense granule lumen] (Gallus gallus)

TIMP3 [platelet dense granule lumen] (Mus musculus)

TIMP3 [platelet dense granule lumen] (Rattus norvegicus)

TIMP3 [platelet dense granule lumen] (Sus scrofa)

TIMP3 [platelet dense granule lumen] (Xenopus tropicalis)

Cross References

RefSeq

NP_000353.1

OpenTargets

ENSG00000100234

HPA

ENSG00000100234-TIMP3

GeneCards

P35625

Ensembl

ENSG00000100234, ENST00000266085, ENSP00000266085

PRO

P35625

Pharos - Targets

P35625

Orphanet

15621

PDB

3CKI

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P50052 AGTR2	1	AGTR2 [plasma membrane] (R-HSA-374130)	0.581	7
UniProt:P13284 IFI30	1	IFI30 [lysosomal lumen] (R-HSA-1031704)	0.527	2
UniProt:P08253 MMP2	5	MMP2(67-109) [extracellular region] (R-HSA-1604371) MMP2(67-660) [extracellular region] (R-HSA-1604345) MMP2(30-66) [extracellular region] (R-HSA-1604347) MMP2(30-660) [extracellular region] (R-HSA-1604364) MMP2(110-660) [extracellular region] (R-HSA-381456)	0.527	2
UniProt:P16035 TIMP2	4	TIMP2 [specific granule lumen] (R-HSA-6799625) TIMP2 [ficolin-1-rich granule lumen] (R-HSA-6800944) TIMP2 [tertiary granule lumen] (R-HSA-6800881) TIMP2 [extracellular region] (R-HSA-1454879)	0.527	2