Reactome | TIMP3 [platelet dense granule lumen]

TIMP3 [platelet dense granule lumen]

Stable Identifier

R-HSA-8848904

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

platelet dense granule lumen

Synonyms

Metalloproteinase inhibitor 3, TIMP3_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P35625 TIMP3

Gene Names

TIMP3

Chain

signal peptide:1-23, chain:24-211

Reference Genes

BioGPS Gene:7078 TIMP3

COSMIC (genes):TIMP3 TIMP3

CTD Gene:7078 TIMP3

dbSNP Gene:7078 TIMP3

ENSEMBL:ENSG00000100234 TIMP3

HGNC:11822 TIMP3

KEGG:hsa:7078 TIMP3

Monarch:7078 TIMP3

NCBI Entrez Gene:7078 TIMP3

OMIM:188826 TIMP3

UCSC:P35625 TIMP3

Reference Transcript

RefSeq:NM_000362.5 TIMP3

Other Identifiers

1034_at

1035_g_at

11715435_s_at

11715436_at

11715437_at

16929442

201147_PM_s_at

201147_s_at

201148_PM_s_at

201148_s_at

201149_PM_s_at

201149_s_at

201150_PM_s_at

201150_s_at

3943506

3943507

3943508

3943533

3943537

3943538

3943540

3943541

3943542

3943543

3943556

7078

8072626

A_23_P399078

D45917_s_at

GE78973

GO:0004857

GO:0005515

GO:0005576

GO:0005604

GO:0005615

GO:0005634

GO:0007601

GO:0008191

GO:0009725

GO:0010716

GO:0030312

GO:0030414

GO:0031012

GO:0031089

GO:0034097

GO:0034774

GO:0045861

GO:0046872

GO:0050877

GO:0051045

GO:0098772

HMNXSV003005589

Hs.245188.0.A2_3p_a_at

Hs.245188.0.A3_3p_a_at

ILMN_1701461

PH_hs_0013028

TC22000248.hg

U14394_at

g1519557_3p_a_at

g9257248_3p_a_at

Participates

as a member of

Platelet dense granule content [platelet dense granule lumen] (Homo sapiens)

Other forms of this molecule

TIMP3 [extracellular region]

Inferred To

Homologues of TIMP3 [platelet dense granule lumen] (Caenorhabditis elegans)

TIMP3 [platelet dense granule lumen] (Bos taurus)

TIMP3 [platelet dense granule lumen] (Caenorhabditis elegans)

TIMP3 [platelet dense granule lumen] (Canis familiaris)

TIMP3 [platelet dense granule lumen] (Drosophila melanogaster)

TIMP3 [platelet dense granule lumen] (Gallus gallus)

TIMP3 [platelet dense granule lumen] (Mus musculus)

TIMP3 [platelet dense granule lumen] (Rattus norvegicus)

TIMP3 [platelet dense granule lumen] (Sus scrofa)

TIMP3 [platelet dense granule lumen] (Xenopus tropicalis)

Cross References

RefSeq

NP_000353.1

ENSEMBL

ENSG00000100234, ENSP00000266085, ENST00000266085

OpenTargets

ENSG00000100234

GeneCards

TIMP3

HPA

ENSG00000100234-TIMP3

PRO

P35625

Pharos - Targets

P35625

Orphanet

TIMP3

PDB

3CKI

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P50052 AGTR2	1	AGTR2 [plasma membrane] (R-HSA-374130)	0.581	7
UniProt:Q04721 NOTCH2	18	NOTCH2(1582-1665) [extracellular region] (R-HSA-157652) NOTCH2(1666-1696) [plasma membrane] (R-HSA-157628) NEXT2 [plasma membrane] (R-HSA-157225) NICD2 [cytosol] (R-HSA-157642) NICD2 [nucleoplasm] (R-HSA-157942) Glc,GlcNAc-Fuc-Pre-NOTCH2 [Golgi membrane] (R-HSA-1911428) Glc,Gal-GlcNAc-Fuc-Pre-NOTCH2 [Golgi membrane] (R-HSA-1911417) Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH2 [Golgi membrane] (R-HSA-1911505) 18xFucT-16xGlcS-FucS-NOTCH2(26-1581) [Golgi membrane] (R-HSA-1983676) NOTCH2(1582-2471) [Golgi membrane] (R-HSA-157017) 18xFucT-16xGlcS-FucS-NOTCH2(26-1581) [extracellular region] (R-HSA-1983678) NOTCH2(1582-2471) [plasma membrane] (R-HSA-157228) 18xFucT-16xGlcS-FucS-NOTCH2(26-2471) [Golgi membrane] (R-HSA-1472874) 18xFucT-16xGlcS-FucS-NOTCH2(26-2471) [endoplasmic reticulum membrane] (R-HSA-1467379) 18xFucT-FucS-NOTCH2(26-2471) [endoplasmic reticulum membrane] (R-HSA-1467363) Pre-NOTCH2 [endoplasmic reticulum membrane] (R-HSA-157025) FRINGE-modified NOTCH2 extracellular fragment (NECD2) [Golgi membrane] (R-HSA-1911520) FRINGE-modified NOTCH2 Extracellular Fragment (NECD2) [plasma membrane] (R-HSA-1911518)	0.527	2
UniProt:P13284 IFI30	1	IFI30 [lysosomal lumen] (R-HSA-1031704)	0.527	2
UniProt:P50281 MMP14	4	MMP14(21-582) [Golgi lumen] (R-HSA-1604689) MMP14 [Golgi lumen] (R-HSA-1604724) MMP14 [plasma membrane] (R-HSA-1442472) MMP14 [Golgi membrane] (R-HSA-9858808)	0.527	2
UniProt:P35813 PPM1A	2	PPM1A [nucleoplasm] (R-HSA-205813) PPM1A [cytosol] (R-HSA-380928)	0.527	3
UniProt:P08253 MMP2	5	MMP2(110-660) [extracellular region] (R-HSA-381456) MMP2(30-660) [extracellular region] (R-HSA-1604364) MMP2(67-660) [extracellular region] (R-HSA-1604345) MMP2(30-66) [extracellular region] (R-HSA-1604347) MMP2(67-109) [extracellular region] (R-HSA-1604371)	0.527	2
UniProt:P78536 ADAM17	6	ADAM17 [plasma membrane] (R-HSA-179878) ADAM17(215-824) [plasma membrane] (R-HSA-9663048) ADAM17 [Golgi membrane] (R-HSA-9662835) ADAM17(1-214) [Golgi membrane] (R-HSA-9662784) ADAM17(215-824) [Golgi membrane] (R-HSA-9662839) ADAM17 [endoplasmic reticulum lumen] (R-HSA-9662763)	0.527	2
UniProt:P16035 TIMP2	4	TIMP2 [ficolin-1-rich granule lumen] (R-HSA-6800944) TIMP2 [specific granule lumen] (R-HSA-6799625) TIMP2 [tertiary granule lumen] (R-HSA-6800881) TIMP2 [extracellular region] (R-HSA-1454879)	0.527	2

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