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AGTR2 [plasma membrane]
Stable Identifier
R-HSA-374130
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Type-2 angiotensin II receptor, AGTR2_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
AGTR2:AGT(34-41) [plasma membrane] (Homo sapiens)
AGTR2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
AGTR2:AGT(34-41) [plasma membrane] (Homo sapiens)
AGTR2 [plasma membrane] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
AGTR2:AGT(34-41) [plasma membrane] (Homo sapiens)
AGTR2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
AGTR2:AGT(34-41) [plasma membrane] (Homo sapiens)
AGTR2 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
AGTR2:AGT(34-41) [plasma membrane] (Homo sapiens)
AGTR2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
AGTR2:AGT(34-41) [plasma membrane] (Homo sapiens)
AGTR2 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
AGT(34-41) binds to AGTR2 (Homo sapiens)
AGTR2 [plasma membrane] (Homo sapiens)
AGTR2:AGT(34-41) [plasma membrane] (Homo sapiens)
AGTR2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P50052 AGTR2
Gene Names
AGTR2
Chain
chain:1-363
Reference Genes
BioGPS Gene:186 AGTR2
COSMIC (genes):AGTR2 AGTR2
CTD Gene:186 AGTR2
dbSNP Gene:186 AGTR2
ENSEMBL:ENSG00000180772 AGTR2
HGNC:338 AGTR2
KEGG:hsa:186 AGTR2
Monarch:186 AGTR2
NCBI Gene:186 AGTR2
OMIM:300034 AGTR2
UCSC:P50052 AGTR2
Reference Transcript
RefSeq:NM_000686.4 AGTR2
RefSeq:XM_011537533.1 AGTR2
Other Identifiers
11733390_a_at
11733391_at
17106392
186
207293_PM_s_at
207293_s_at
207294_PM_at
207294_at
222321_PM_at
222321_at
33496_at
3988153
3988154
3988155
3988156
3988157
3988158
3988159
3988161
3988162
76438_at
8169492
A_14_P119098
A_14_P201924
A_23_P62309
A_33_P3376493
GE58229
GO:0001974
GO:0001991
GO:0002033
GO:0002035
GO:0003013
GO:0004930
GO:0004945
GO:0005515
GO:0005886
GO:0006355
GO:0006954
GO:0007166
GO:0007186
GO:0007199
GO:0007420
GO:0008217
GO:0010459
GO:0012501
GO:0016020
GO:0030308
GO:0032516
GO:0035566
GO:0035640
GO:0038060
GO:0038166
GO:0042311
GO:0042981
GO:0043537
GO:0045893
GO:0048019
GO:0048856
GO:0050877
GO:0050886
GO:0051387
GO:0051402
GO:0060089
GO:0072300
GO:0090190
GO:0097746
GO:0098772
GO:2001238
HMNXSV003014467
Hs.122158.0.A1_3p_at
ILMN_1775634
PH_hs_0024647
TC0X000570.hg
TC0X001845.hg
U20860_at
g595934_3p_a_at
g6715584_3p_at
Participates
as an input of
AGT(34-41) binds to AGTR2 (Homo sapiens)
as a component of
AGTR2:AGT(34-41) [plasma membrane] (Homo sapiens)
Inferred To
Tre1 [plasma membrane]
(Drosophila melanogaster)
moody [plasma membrane]
(Drosophila melanogaster)
Homologues of AGTR2 [plasma membrane]
(Drosophila melanogaster)
npr-25 [plasma membrane]
(Caenorhabditis elegans)
AGTR2 [plasma membrane]
(Bos taurus)
AGTR2 [plasma membrane]
(Canis familiaris)
AGTR2 [plasma membrane]
(Gallus gallus)
AGTR2 [plasma membrane]
(Mus musculus)
AGTR2 [plasma membrane]
(Rattus norvegicus)
AGTR2 [plasma membrane]
(Sus scrofa)
agtr2 [plasma membrane]
(Danio rerio)
EG:22E5.10 [plasma membrane]
(Drosophila melanogaster)
Cross References
RefSeq
NP_000677.2
,
XP_011535835.1
ZINC - World Drugs
AGTR2_HUMAN
Guide to Pharmacology - Targets
35
ENSEMBL
ENST00000681852
,
ENSP00000505750
,
ENST00000371906
,
ENSP00000360973
OpenTargets
ENSG00000180772
ZINC - FDA approved
AGTR2_HUMAN
ZINC - Substances
AGTR2_HUMAN
ZINC target
P50052
PRO
P50052
GlyGen
P50052
PDB
7JNI
,
5UNG
,
6JOD
,
5UNF
,
5XJM
,
7C6A
,
5UNH
HPA
ENSG00000180772-AGTR2
Pharos - Targets
P50052
Orphanet
AGTR2
ZINC - Predictions - Purchasable
AGTR2_HUMAN
HMDB Protein
HMDBP10882
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P35625 TIMP3
2
TIMP3 [extracellular region]
(R-HSA-1430774)
TIMP3 [platelet dense granule lumen]
(R-HSA-8848904)
0.581
7
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