Reactome | MMP14 [plasma membrane]

MMP14 [plasma membrane]

Stable Identifier

R-HSA-1442472

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Matrix metalloproteinase-14, MMP14_HUMAN, MT1-MMP, Membrane-type-1 matrix metalloproteinase

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P50281 MMP14

Gene Names

MMP14

Chain

signal peptide:1-20, propeptide:21-111, chain:112-582

Reference Genes

BioGPS Gene:4323 MMP14

COSMIC (genes):MMP14 MMP14

CTD Gene:4323 MMP14

dbSNP Gene:4323 MMP14

ENSEMBL:ENSG00000157227 MMP14

ENSEMBL_homo_sapiens_GENE:ENSG00000157227.14 MMP14

HGNC:7160 MMP14

KEGG Gene (Homo sapiens):4323 MMP14

Monarch:4323 MMP14

NCBI Gene:4323 MMP14

OMIM:600754 MMP14

UCSC:P50281 MMP14

Reference Transcript

RefSeq:NM_004995.3 MMP14

Other Identifiers

11725987_a_at

11725988_at

11725989_x_at

11747717_a_at

1301_s_at

160020_PM_at

160020_at

16782187

202827_PM_s_at

202827_s_at

202828_PM_s_at

202828_s_at

217279_3p_x_at

217279_PM_x_at

217279_x_at

34747_at

3528865

3528866

3528871

3528872

3528873

3528875

3528876

3528877

3528878

3528879

3528880

3528881

3528882

3528883

3528884

3528885

3528886

3528887

3528888

3528890

3528892

4323

4870053_3p_s_at

73002_at

7973336

A_14_P114314

A_24_P82106

GE60414

GO:0001501

GO:0001503

GO:0001525

GO:0001541

GO:0001666

GO:0001935

GO:0001958

GO:0002376

GO:0003824

GO:0004175

GO:0004222

GO:0004252

GO:0005178

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005768

GO:0005794

GO:0005796

GO:0005829

GO:0005856

GO:0005886

GO:0005925

GO:0006508

GO:0006979

GO:0007155

GO:0008233

GO:0008237

GO:0008270

GO:0008584

GO:0009612

GO:0009725

GO:0010831

GO:0010954

GO:0014070

GO:0016020

GO:0016477

GO:0016485

GO:0016787

GO:0022414

GO:0022617

GO:0023052

GO:0030154

GO:0030198

GO:0030307

GO:0030312

GO:0030324

GO:0030335

GO:0030574

GO:0031012

GO:0031410

GO:0031638

GO:0034330

GO:0035987

GO:0035988

GO:0042470

GO:0043226

GO:0043615

GO:0043627

GO:0044354

GO:0045111

GO:0045579

GO:0045746

GO:0046872

GO:0048701

GO:0048754

GO:0048771

GO:0048856

GO:0048870

GO:0051604

GO:0051895

GO:0060322

GO:0060348

GO:0070006

GO:0072659

GO:0097094

GO:0140096

GO:1903076

GO:1905523

GO:1990834

HMNXSV003041452

Hs.2399.0.S2_3p_s_at

Hs.2399.1.S1_3p_a_at

Hs.2399.1.S1_3p_s_at

ILMN_1774739

PH_hs_0000323

TC14000133.hg

X83535_s_at

Z48481_at

Participates

as a member of

as an output of

MMP14 translocates from the Golgi membrane to the plasma membrane (Homo sapiens)

as a component of

MMP14:TIMP2 [plasma membrane] (Homo sapiens)

as an input of

MMP14 (MT1-MMP) binds TIMP2 (Homo sapiens)

Other forms of this molecule

MMP14 [Golgi membrane]

MMP14(21-582) [Golgi lumen]

MMP14 [Golgi lumen]

Inferred To

Mmp14 [plasma membrane] (Mus musculus)

Homologues of MMP14 [plasma membrane] (Caenorhabditis elegans)

Homologues of MMP14 [plasma membrane] (Drosophila melanogaster)

MMP14 [plasma membrane] (Bos taurus)

MMP14 [plasma membrane] (Caenorhabditis elegans)

MMP14 [plasma membrane] (Canis familiaris)

MMP14 [plasma membrane] (Danio rerio)

MMP14 [plasma membrane] (Drosophila melanogaster)

MMP14 [plasma membrane] (Rattus norvegicus)

MMP14 [plasma membrane] (Sus scrofa)

MMP14 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_004986.1

ZINC - World Drugs

MMP14_HUMAN

Guide to Pharmacology - Targets

1638

OpenTargets

ENSG00000157227

ZINC - Substances

MMP14_HUMAN

ZINC target

P50281

ZINC - Biogenic

MMP14_HUMAN

PRO

P50281

PDB

5H0U, 6CM1, 3X23, 3C7X, 2MQS, 6CLZ, 4P3D, 3MA2, 1BUV, 4QXU, 4P3C, 1BQQ

ZINC - Investigational

MMP14_HUMAN

ZINC - Metabolites

MMP14_HUMAN

HPA

ENSG00000157227-MMP14

GeneCards

P50281

Ensembl

ENSP00000308208, ENST00000311852, ENSG00000157227

Pharos - Targets

P50281

ZINC - Predictions - Purchasable

MMP14_HUMAN

Orphanet

21522

HMDB Protein

HMDBP02912

Interactors (21)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BV57 ADI1	1	ADI1 [cytosol] (R-HSA-1237109)	0.602	4
UniProt:Q9R064	2	phospho-Gorasp2 [Golgi membrane] (R-RNO-2422965) Gorasp2 [Golgi membrane] (R-RNO-2422385)	0.602	14
UniProt:P09958 FURIN	6	FURIN [macropinosome membrane] (R-HSA-9837714) FURIN [trans-Golgi network membrane] (R-HSA-9832627) FURIN [Golgi lumen] (R-HSA-448351) FURIN [plasma membrane] (R-HSA-2159856) FURIN [extracellular region] (R-HSA-1181103) FURIN [Golgi membrane] (R-HSA-157049)	0.564	3
UniProt:P16035 TIMP2	4	TIMP2 [specific granule lumen] (R-HSA-6799625) TIMP2 [ficolin-1-rich granule lumen] (R-HSA-6800944) TIMP2 [tertiary granule lumen] (R-HSA-6800881) TIMP2 [extracellular region] (R-HSA-1454879)	0.564	4
UniProt:P51884 LUM	12	LUM [extracellular region] (R-HSA-2466189) N-glycan LUM [Golgi lumen] (R-HSA-2046297) Gal-glycan LUM [Golgi lumen] (R-HSA-2046248) Keratan(1)-LUM [Golgi lumen] (R-HSA-2046316) Keratan(2)-LUM [Golgi lumen] (R-HSA-2046233) Keratan(3)-LUM [Golgi lumen] (R-HSA-2046198) Keratan(4)-LUM [Golgi lumen] (R-HSA-2046205) KS(1)-LUM [Golgi lumen] (R-HSA-2046161) KS(2)-LUM [Golgi lumen] (R-HSA-2046249) KS(2)-LUM [extracellular region] (R-HSA-2046202) KS(2)-LUM [lysosomal lumen] (R-HSA-2046283) LUM [lysosomal lumen] (R-HSA-2104998)	0.558	2
IntAct:EBI-22326698 CCSB ORF ID			0.556	3
UniProt:Q7Z5P4 HSD17B13	1	HSD17B13 [cytosol] (R-HSA-8862029)	0.556	3
UniProt:P27105 STOM	4	STOM [tertiary granule membrane] (R-HSA-6800960) STOM [plasma membrane] (R-HSA-6806258) STOM [azurophil granule membrane] (R-HSA-6800997) STOM [specific granule membrane] (R-HSA-6799569)	0.556	3
UniProt:Q9GZR5 ELOVL4	1	ELOVL4 [endoplasmic reticulum membrane] (R-HSA-548705)	0.556	3
UniProt:Q96AP4 ZUP1			0.556	3
UniProt:Q13520 AQP6	1	AQP6 [transport vesicle membrane] (R-HSA-431741)	0.556	3
UniProt:Q13643 FHL3			0.556	3
UniProt:Q8N6L0 KASH5			0.556	3
UniProt:Q15800 MSMO1	1	MSMO1 [endoplasmic reticulum membrane] (R-HSA-194648)	0.556	3
UniProt:Q15125 EBP	1	EBP [endoplasmic reticulum membrane] (R-HSA-195697)	0.556	3
UniProt:Q9Y624 F11R	2	F11R [cell junction] (R-HSA-2134498) F11R [plasma membrane] (R-HSA-197845)	0.556	3
UniProt:Q07021 C1QBP	3	C1QBP [cytosol] (R-HSA-9645690) C1QBP [mitochondrial matrix] (R-HSA-9645697) C1QBP [plasma membrane] (R-HSA-158123)	0.544	2
UniProt:Q9H8Y8 GORASP2	2	GORASP2 [Golgi membrane] (R-HSA-2422385) p-T222,T225-GORASP2 [Golgi membrane] (R-HSA-2422965)	0.463	2
UniProt:P56945 BCAR1	4	p-Y-BCAR1 [cytosol] (R-HSA-372645) p-Y12-BCAR1 [cytosol] (R-HSA-5218739) p-Y165,Y664-BCAR1 [cytosol] (R-HSA-8848723) BCAR1 [cytosol] (R-HSA-201625)	0.463	3
UniProt:P53667 LIMK1	3	p-S,T508-LIMK1 [cytosol] (R-HSA-419610) p-T508-LIMK1 [cytosol] (R-HSA-399816) LIMK1 [cytosol] (R-HSA-397785)	0.463	4
UniProt:P21926 CD9	4	CD9 [plasma membrane] (R-HSA-51717) CD9 [endocytic vesicle membrane] (R-HSA-5334774) CD9 [clathrin-coated endocytic vesicle membrane] (R-HSA-5334779) CD9 [platelet alpha granule membrane] (R-HSA-114585)	0.462	2

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