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Transport of organic anions
Stable Identifier
R-HSA-879518
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
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Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Transport of vitamins, nucleosides, and related molecules (Homo sapiens)
Transport of organic anions (Homo sapiens)
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Organic anion transporting polypeptides (OATPs) are membrane transport proteins that mediate the sodium-independent transport of a wide range of amphipathic organic compounds including bile salts, steroid conjugates, thyroid hormones, anionic oligopeptides and numerous drugs (Hagenbuch B and Meier PJ, 2004).
Literature References
PubMed ID
Title
Journal
Year
14579113
Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties
Meier, PJ
,
Hagenbuch, B
Pflugers Arch
2004
Participants
Events
Transport (influx) of bile salts and acids by OATP-A
(Homo sapiens)
SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol
(Homo sapiens)
SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol
(Homo sapiens)
SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol
(Homo sapiens)
SLCO1B1 transports T3,T4 from extracellular region to cytosol
(Homo sapiens)
SLCO2A1 transports PGT substrates from extracellular region to cytosol
(Homo sapiens)
SLCO2B1 has a narrow substrate specificity
(Homo sapiens)
SLCO3A1 isoform 1 has abroad substrate specificity
(Homo sapiens)
SLCO4C1 mediates the transport of digoxin
(Homo sapiens)
Participates
as an event of
Transport of vitamins, nucleosides, and related molecules (Homo sapiens)
Event Information
Go Biological Process
sodium-independent organic anion transport (0043252)
Orthologous Events
Transport of organic anions (Bos taurus)
Transport of organic anions (Caenorhabditis elegans)
Transport of organic anions (Canis familiaris)
Transport of organic anions (Danio rerio)
Transport of organic anions (Dictyostelium discoideum)
Transport of organic anions (Drosophila melanogaster)
Transport of organic anions (Gallus gallus)
Transport of organic anions (Mus musculus)
Transport of organic anions (Plasmodium falciparum)
Transport of organic anions (Rattus norvegicus)
Transport of organic anions (Saccharomyces cerevisiae)
Transport of organic anions (Sus scrofa)
Transport of organic anions (Xenopus tropicalis)
Authored
Jassal, B (2010-06-18)
Reviewed
He, L (2010-07-07)
Created
Jassal, B (2010-06-18)
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