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Organic anion transport by SLCO transporters
Stable Identifier
R-HSA-879518
Type
Pathway
Species
Homo sapiens
Synonyms
Transport of organic anions
ReviewStatus
5/5
Locations in the PathwayBrowser
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Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
SLC-mediated transport of organic anions (Homo sapiens)
Organic anion transport by SLCO transporters (Homo sapiens)
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Organic anion transporting polypeptides (OATPs) are membrane transport proteins that mediate the sodium-independent transport of a wide range of amphipathic organic compounds including bile salts, steroid conjugates, thyroid hormones, anionic oligopeptides and numerous drugs (Hagenbuch B and Meier PJ, 2004).
Literature References
PubMed ID
Title
Journal
Year
14579113
Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties
Hagenbuch, B
,
Meier, PJ
Pflugers Arch
2004
Participants
Events
Transport (influx) of bile salts and acids by OATP-A
(Homo sapiens)
SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol
(Homo sapiens)
SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol
(Homo sapiens)
SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol
(Homo sapiens)
SLCO1B1 transports T3,T4 from extracellular region to cytosol
(Homo sapiens)
SLCO2A1 transports PGT substrates from extracellular region to cytosol
(Homo sapiens)
SLCO2B1 has a narrow substrate specificity
(Homo sapiens)
SLCO3A1 isoform 1 has a broad substrate specificity
(Homo sapiens)
SLCO4C1 mediates the transport of digoxin
(Homo sapiens)
Participates
as an event of
SLC-mediated transport of organic anions (Homo sapiens)
Event Information
Go Biological Process
sodium-independent organic anion transport (0043252)
Orthologous Events
Organic anion transport by SLCO transporters (Bos taurus)
Organic anion transport by SLCO transporters (Caenorhabditis elegans)
Organic anion transport by SLCO transporters (Canis familiaris)
Organic anion transport by SLCO transporters (Danio rerio)
Organic anion transport by SLCO transporters (Drosophila melanogaster)
Organic anion transport by SLCO transporters (Gallus gallus)
Organic anion transport by SLCO transporters (Mus musculus)
Organic anion transport by SLCO transporters (Rattus norvegicus)
Organic anion transport by SLCO transporters (Saccharomyces cerevisiae)
Organic anion transport by SLCO transporters (Sus scrofa)
Organic anion transport by SLCO transporters (Xenopus tropicalis)
Authored
Jassal, B (2010-06-18)
Reviewed
He, L (2010-07-07)
Created
Jassal, B (2010-06-18)
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