A molecule of extracellular glycocholate (GCCA) or taurocholate (TCCA) is transported into the cytosol, mediated by OATP-C (SLCO1B1) in the plasma membrane. GCCA and TCCA exist in the blood as complexes with serum albumin (ALB), and its uptake by OATP-C must involve disruption of this complex, but the molecular mechanism coupling disruption and uptake is unknown. In the body, OATP-C is expressed on the basolateral surfaces of hepatocytes and may play a role in the uptake of GCCA and TCCA by the liver under physiological conditions (Kullak-Ublick et al. 2004, Trauner & Boyer 2002).
Fattinger, K, Landmann, L, Huber, R, Meier, PJ, Hagenbuch, B, Kullak-Ublick, GA, Ismair, MG, Pizzagalli, F, Stieger, B
Unno, M, Naitoh, T, Yawo, H, Tokui, T, Nishio, T, Abe, T, Suzuki, M, Nakagomi, R, Nakai, D, Nomura, H, Kakyo, M, Matsuno, S
Yang, WP, Wu, Y, Hsiang, B, Sasseville, V, Kirchgessner, TG, Wang, Z, Zhu, Y
bile acid transmembrane transporter activity of SLCO1B1 [plasma membrane]
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