SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol

Stable Identifier
Reaction [transition]
Homo sapiens
Transport (influx) of glycocholate and taurocholate by OATP-C
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A molecule of extracellular glycocholate (GCCA) or taurocholate (TCCA) is transported into the cytosol, mediated by OATP-C (SLCO1B1) in the plasma membrane. GCCA and TCCA exist in the blood as complexes with serum albumin (ALB), and its uptake by OATP-C must involve disruption of this complex, but the molecular mechanism coupling disruption and uptake is unknown. In the body, OATP-C is expressed on the basolateral surfaces of hepatocytes and may play a role in the uptake of GCCA and TCCA by the liver under physiological conditions (Kullak-Ublick et al. 2004, Trauner & Boyer 2002).

Literature References
PubMed ID Title Journal Year
11159893 Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver

Fattinger, K, Landmann, L, Huber, R, Meier, PJ, Hagenbuch, B, Kullak-Ublick, GA, Ismair, MG, Pizzagalli, F, Stieger, B

Gastroenterology 2001
10358072 Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1

Unno, M, Naitoh, T, Yawo, H, Tokui, T, Nishio, T, Abe, T, Suzuki, M, Nakagomi, R, Nakai, D, Nomura, H, Kakyo, M, Matsuno, S

J Biol Chem 1999
10601278 A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters

Yang, WP, Wu, Y, Hsiang, B, Sasseville, V, Kirchgessner, TG, Wang, Z, Zhu, Y

J Biol Chem 1999
Catalyst Activity

bile acid transmembrane transporter activity of SLCO1B1 [plasma membrane]

Orthologous Events
Cross References
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