SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol

Stable Identifier
R-HSA-194083
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Transport (influx) of glycocholate and taurocholate by OATP-C
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A molecule of extracellular glycocholate (GCCA) or taurocholate (TCCA) is transported into the cytosol, mediated by OATP-C (SLCO1B1) in the plasma membrane. GCCA and TCCA exist in the blood as complexes with serum albumin (ALB), and its uptake by OATP-C must involve disruption of this complex, but the molecular mechanism coupling disruption and uptake is unknown. In the body, OATP-C is expressed on the basolateral surfaces of hepatocytes and may play a role in the uptake of GCCA and TCCA by the liver under physiological conditions (Kullak-Ublick et al. 2004, Trauner & Boyer 2002).

Literature References
PubMed ID Title Journal Year
10358072 Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1

Abe, T, Kakyo, M, Tokui, T, Nakagomi, R, Nishio, T, Nakai, D, Nomura, H, Unno, M, Suzuki, M, Naitoh, T, Matsuno, S, Yawo, H

J Biol Chem 1999
11159893 Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver

Kullak-Ublick, GA, Ismair, MG, Stieger, B, Landmann, L, Huber, R, Pizzagalli, F, Fattinger, K, Meier, PJ, Hagenbuch, B

Gastroenterology 2001
10601278 A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters

Hsiang, B, Zhu, Y, Wang, Z, Wu, Y, Sasseville, V, Yang, WP, Kirchgessner, TG

J Biol Chem 1999
Participants
Participates
Catalyst Activity

bile acid transmembrane transporter activity of SLCO1B1 [plasma membrane]

Orthologous Events
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