Reactome | SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol

SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol

Stable Identifier

R-HSA-194083

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Transport (influx) of glycocholate and taurocholate by OATP-C

ReviewStatus

5/5

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SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol

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A molecule of extracellular glycocholate (GCCA) or taurocholate (TCCA) is transported into the cytosol, mediated by OATP-C (SLCO1B1) in the plasma membrane. GCCA and TCCA exist in the blood as complexes with serum albumin (ALB), and its uptake by OATP-C must involve disruption of this complex, but the molecular mechanism coupling disruption and uptake is unknown. In the body, OATP-C is expressed on the basolateral surfaces of hepatocytes and may play a role in the uptake of GCCA and TCCA by the liver under physiological conditions (Kullak-Ublick et al. 2004, Trauner & Boyer 2002).

Literature References

PubMed ID	Title	Journal	Year
11159893	Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver Kullak-Ublick, GA, Ismair, MG, Stieger, B, Landmann, L, Huber, R, Pizzagalli, F, Fattinger, K, Meier, PJ, Hagenbuch, B	Gastroenterology	2001
10358072	Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1 Abe, T, Kakyo, M, Tokui, T, Nakagomi, R, Nishio, T, Nakai, D, Nomura, H, Unno, M, Suzuki, M, Naitoh, T, Matsuno, S, Yawo, H	J Biol Chem	1999
10601278	A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters Hsiang, B, Zhu, Y, Wang, Z, Wu, Y, Sasseville, V, Yang, WP, Kirchgessner, TG	J Biol Chem	1999