Reactome | SLCO2B1 has a narrow substrate specificity

SLCO2B1 has a narrow substrate specificity

Stable Identifier

R-HSA-879562

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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SLCO2B1 has a narrow substrate specificity

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SLCO2B1 (formerly OATP-B) is abundantly expressed in human liver, where it is localized at the basolateral membrane of hepatocytes. It has a narrow substrate range, able to transport bromosulphophthalein (BSP), estrone-3-sulphate and dehydroepiandrosterone-sulphate (DHEAS) (Kullak-Ublick GA et al, 2001).

Literature References

PubMed ID	Title	Journal	Year
11159893	Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver Kullak-Ublick, GA, Ismair, MG, Stieger, B, Landmann, L, Huber, R, Pizzagalli, F, Fattinger, K, Meier, PJ, Hagenbuch, B	Gastroenterology	2001