SLCO2B1 has a narrow substrate specificity

Stable Identifier
R-HSA-879562
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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SLCO2B1 (formerly OATP-B) is abundantly expressed in human liver, where it is localized at the basolateral membrane of hepatocytes. It has a narrow substrate range, able to transport bromosulphophthalein (BSP), estrone-3-sulphate and dehydroepiandrosterone-sulphate (DHEAS) (Kullak-Ublick GA et al, 2001).

Literature References
PubMed ID Title Journal Year
11159893 Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver

Kullak-Ublick, GA, Ismair, MG, Stieger, B, Landmann, L, Huber, R, Pizzagalli, F, Fattinger, K, Meier, PJ, Hagenbuch, B

Gastroenterology 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
sodium-independent organic anion transmembrane transporter activity of SLCO2B1 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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