Reactome | SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol

SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol

Stable Identifier

R-HSA-194079

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol

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A molecule of extracellular glycocholate or taurocholate is transported into the cytosol, mediated by OATP-8 (SLCO1B3) in the plasma membrane. Glycocholate and taurocholate exist in the blood as complexes with serum albumin, and their uptake by OATP-8 must involve disruption of these complexes, but the molecular mechanism coupling disruption and uptake is unknown. In the body, OATP-8 is expressed on the basolateral surfaces of hepatocytes and may play a role in the uptake of glycocholate and taurocholate by the liver under physiological conditions (Kullak-Ublick et al. 2004; Trauner and Boyer 2002).

Literature References

PubMed ID	Title	Journal	Year
11159893	Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver Kullak-Ublick, GA, Ismair, MG, Stieger, B, Landmann, L, Huber, R, Pizzagalli, F, Fattinger, K, Meier, PJ, Hagenbuch, B	Gastroenterology	2001