SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol

Stable Identifier
R-HSA-879575
Type
Reaction [transition]
Species
Homo sapiens
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Three organic anion transporting polypeptides (OATPs; now called solute carrier organic anion transporters, SLCOs) are able to mediate the transport of thyroid hormones, predominantly thyroxine (T4) and triiodothyronine (T3) (Fujiwara et al. 2001). SLCO1B1 (formerly OATP-C), which can also transport bile salts, is mainly expressed in the liver (Abe et al. 1999; Hsiang et al. 1999). SLCO4A1 (formerly OATP-E) is mainly expressed in peripheral tissue and has a broad substrate specificty (Tamai et al. 2000). SLCO1C1 (formerly OATP-F) is highly expressed in brain and is also a high affinity thyroid hormone transporter (Pizzagalli et al. 2002).

The monocarboxylate transporter 8 (MCT8, SLC16A2 is also a very active and specific thyroid hormone transporter in its dimeric form (Visser et al. 2009). Defects in SLC16A2 can cause severe X-linked psychomotor retardation. SLC16A2 mutations that inhibited SLC16A2 dimerisation resulted in defective transport function of SLC16A2 (Fischer et al. 2015).

Literature References
PubMed ID Title Journal Year
10873595 Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family

Tamai, I, Nezu, J, Uchino, H, Sai, Y, Oku, A, Shimane, M, Tsuji, A

Biochem Biophys Res Commun 2000
12351693 Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter

Pizzagalli, F, Hagenbuch, B, Stieger, B, Klenk, U, Folkers, G, Meier, PJ

Mol Endocrinol 2002
10358072 Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1

Abe, T, Kakyo, M, Tokui, T, Nakagomi, R, Nishio, T, Nakai, D, Nomura, H, Unno, M, Suzuki, M, Naitoh, T, Matsuno, S, Yawo, H

J Biol Chem 1999
19797118 Evidence for a homodimeric structure of human monocarboxylate transporter 8

Visser, WE, Philp, NJ, van Dijk, TB, Klootwijk, W, Friesema, EC, Jansen, J, Beesley, PW, Ianculescu, AG, Visser, TJ

Endocrinology 2009
10601278 A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters

Hsiang, B, Zhu, Y, Wang, Z, Wu, Y, Sasseville, V, Yang, WP, Kirchgessner, TG

J Biol Chem 1999
25527620 Modulation of monocarboxylate transporter 8 oligomerization by specific pathogenic mutations

Fischer, J, Kleinau, G, Müller, A, Kühnen, P, Zwanziger, D, Kinne, A, Rehders, M, Moeller, LC, Führer, D, Gruters, A, Krude, H, Brix, K, Biebermann, H

J. Mol. Endocrinol. 2015
11316767 Identification of thyroid hormone transporters in humans: different molecules are involved in a tissue-specific manner

Fujiwara, K, Adachi, H, Nishio, T, Unno, M, Tokui, T, Okabe, M, Onogawa, T, Suzuki, T, Asano, N, Tanemoto, M, Seki, M, Shiiba, K, Suzuki, M, Kondo, Y, Nunoki, K, Shimosegawa, T, Iinuma, K, Ito, S, Matsuno, S, Abe, T

Endocrinology 2001
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Title
thyroid hormone transmembrane transporter activity of SLCOs, SLC16A2 dimer [plasma membrane]
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