Transport (influx) of bile salts and acids by OATP-A

Stable Identifier
R-HSA-194130
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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A molecule of extracellular bile salt (glyco- or taurocholate or taurochenodeoxycholate) or bile acid (cholate or chenodeoxycholate) is transported into the cytosol, mediated by OATP-A (SLCO1A2) in the plasma membrane. Bile salts and acids exist in the blood as complexes with serum albumin, and their uptake by OATP-A must involve disruption of this complex, but the molecular mechanism coupling release of a bile salt or acid from albumin to its uptake by OATP-A is unknown. In the body, OATP-A is expressed only at low levels on the basolateral surfaces of hepatocytes and may play only a minor role in the uptake of bile salts and acids by the liver (Kullak-Ublick et al. 2004; Trauner and Boyer 2002).

Literature References
PubMed ID Title Journal Year
7557095 Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver

Kullak-Ublick, GA, Hagenbuch, B, Stieger, B, Schteingart, CD, Hofmann, AF, Wolkoff, AW, Meier, PJ

Gastroenterology 1995
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
bile acid transmembrane transporter activity of SLCO1A2 [plasma membrane]
Physical Entity
Activity
Orthologous Events
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Reviewed
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