Reactome | SLCO1B1 transports T3,T4 from extracellular region to cytosol

SLCO1B1 transports T3,T4 from extracellular region to cytosol

Stable Identifier

R-HSA-9631987

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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SLCO1B1 transports T3,T4 from extracellular region to cytosol

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Three organic anion transporting polypeptides (OATPs; now called solute carrier organic anion transporters, SLCOs) are able to mediate the transport of thyroid hormones, predominantly thyroxine (T4) and triiodothyronine (T3) (Fujiwara et al. 2001). SLCO1B1 (formerly OATP-C), which can also transport bile salts, is mainly expressed in the liver (Abe et al. 1999, Hsiang et al. 1999).

Literature References

PubMed ID	Title	Journal	Year
10358072	Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1 Unno, M, Naitoh, T, Yawo, H, Tokui, T, Nishio, T, Abe, T, Suzuki, M, Nakagomi, R, Nakai, D, Nomura, H, Kakyo, M, Matsuno, S	J Biol Chem	1999
10601278	A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters Yang, WP, Wu, Y, Hsiang, B, Sasseville, V, Kirchgessner, TG, Wang, Z, Zhu, Y	J Biol Chem	1999
11316767	Identification of thyroid hormone transporters in humans: different molecules are involved in a tissue-specific manner Unno, M, Onogawa, T, Fujiwara, K, Tokui, T, Okabe, M, Nishio, T, Seki, M, Kondo, Y, Tanemoto, M, Suzuki, T, Nunoki, K, Asano, N, Abe, T, Shimosegawa, T, Suzuki, M, Shiiba, K, Adachi, H, Ito, S, Iinuma, K, Matsuno, S	Endocrinology	2001