SLCO1B1 transports T3,T4 from extracellular region to cytosol

Stable Identifier
R-HSA-9631987
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Three organic anion transporting polypeptides (OATPs; now called solute carrier organic anion transporters, SLCOs) are able to mediate the transport of thyroid hormones, predominantly thyroxine (T4) and triiodothyronine (T3) (Fujiwara et al. 2001). SLCO1B1 (formerly OATP-C), which can also transport bile salts, is mainly expressed in the liver (Abe et al. 1999, Hsiang et al. 1999).

Literature References
PubMed ID Title Journal Year
10601278 A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters

Hsiang, B, Zhu, Y, Wang, Z, Wu, Y, Sasseville, V, Yang, WP, Kirchgessner, TG

J Biol Chem 1999
10358072 Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1

Abe, T, Kakyo, M, Tokui, T, Nakagomi, R, Nishio, T, Nakai, D, Nomura, H, Unno, M, Suzuki, M, Naitoh, T, Matsuno, S, Yawo, H

J Biol Chem 1999
11316767 Identification of thyroid hormone transporters in humans: different molecules are involved in a tissue-specific manner

Fujiwara, K, Adachi, H, Nishio, T, Unno, M, Tokui, T, Okabe, M, Onogawa, T, Suzuki, T, Asano, N, Tanemoto, M, Seki, M, Shiiba, K, Suzuki, M, Kondo, Y, Nunoki, K, Shimosegawa, T, Iinuma, K, Ito, S, Matsuno, S, Abe, T

Endocrinology 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
thyroid hormone transmembrane transporter activity of SLCO1B1 [plasma membrane]
Physical Entity
Activity
Orthologous Events
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