SLCO4C1 mediates the transport of digoxin

Stable Identifier
R-HSA-879594
Type
Reaction [transition]
Species
Homo sapiens
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Digoxin is a commonly prescribed drug for the treatment of heart failure. It is mainly eliminated from the body by the kidneys. Human SLCO4C1 (formerly OATP-H) is the first member of the organic anion transporting polypeptide (OATP) family expressed in human kidney. It is found on the baolateral membrane of the nephron and is thought to be the first step of the transport of digoxin into urine (Mikkaichi T et al, 2004).

Literature References
PubMed ID Title Journal Year
14993604 Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney

Mikkaichi, T, Suzuki, T, Onogawa, T, Tanemoto, M, Mizutamari, H, Okada, M, Chaki, T, Masuda, S, Tokui, T, Eto, N, Abe, M, Satoh, F, Unno, M, Hishinuma, T, Inui, K, Ito, S, Goto, J, Abe, T

Proc Natl Acad Sci U S A 2004
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Catalyst Activity
Title
sodium-independent organic anion transmembrane transporter activity of SLCO4C1 [plasma membrane]
Physical Entity
Activity
Orthologous Events
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