Reactome | SLCO4C1 mediates the transport of digoxin

SLCO4C1 mediates the transport of digoxin

Stable Identifier

R-HSA-879594

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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SLCO4C1 mediates the transport of digoxin

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Digoxin is a commonly prescribed drug for the treatment of heart failure. It is mainly eliminated from the body by the kidneys. Human SLCO4C1 (formerly OATP-H) is the first member of the organic anion transporting polypeptide (OATP) family expressed in human kidney. It is found on the baolateral membrane of the nephron and is thought to be the first step of the transport of digoxin into urine (Mikkaichi T et al, 2004).

Literature References

PubMed ID	Title	Journal	Year
14993604	Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney Unno, M, Okada, M, Onogawa, T, Eto, N, Tokui, T, Hishinuma, T, Masuda, S, Goto, J, Tanemoto, M, Suzuki, T, Inui, K, Chaki, T, Abe, T, Mizutamari, H, Ito, S, Abe, M, Satoh, F, Mikkaichi, T	Proc Natl Acad Sci U S A	2004