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Fatty acyl-CoA biosynthesis
Stable Identifier
R-HSA-75105
DOI
10.3180/R-HSA-75105.11
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
,
endoplasmic reticulum membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Fatty acid metabolism (Homo sapiens)
Fatty acyl-CoA biosynthesis (Homo sapiens)
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Fatty acyl-CoA biosynthesis involves following steps:
-Palmitate synthesis catalyzed by Acetyl-CoA carboxylase and Fatty acid synthase
-Conversion of palmitic acid to long chain fatty acids and
-Conversion of long chain fatty acids to fatty acyl-CoA by acyl-CoA synthases.
Literature References
PubMed ID
Title
Journal
Year
25360565
Fatty acid biosynthesis revisited: structure elucidation and metabolic engineering
Beld, J
,
Lee, DJ
,
Burkart, MD
Mol Biosyst
2015
Participants
Events
ACLY tetramer transforms CIT to Ac-CoA
(Homo sapiens)
SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA
(Homo sapiens)
ACLY tetramer binds ETC-1002-CoA
(Homo sapiens)
Formation of Malonyl-CoA from Acetyl-CoA (liver)
(Homo sapiens)
Formation of fatty acid synthase (FAS) dimer
(Homo sapiens)
Conversion of malonyl-CoA and acetyl-CoA to palmitate
(Homo sapiens)
OLAH hydrolyzes decanoyl-FASN dimer to DECA and FASN dimer
(Homo sapiens)
Synthesis of very long-chain fatty acyl-CoAs
(Homo sapiens)
SCD desaturates ST-CoA to OLE-CoA
(Homo sapiens)
SCD5 desaturates ST-CoA to OLE-CoA
(Homo sapiens)
PPT1 hydrolyses palmitoylated proteins
(Homo sapiens)
PPT2 hydrolyses PALMCoA to PALM
(Homo sapiens)
2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP
(Homo sapiens)
RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA
(Homo sapiens)
Participates
as an event of
Fatty acid metabolism (Homo sapiens)
Event Information
Go Biological Process
fatty-acyl-CoA biosynthetic process (0046949)
Orthologous Events
Fatty acyl-CoA biosynthesis (Bos taurus)
Fatty acyl-CoA biosynthesis (Caenorhabditis elegans)
Fatty acyl-CoA biosynthesis (Canis familiaris)
Fatty acyl-CoA biosynthesis (Danio rerio)
Fatty acyl-CoA biosynthesis (Dictyostelium discoideum)
Fatty acyl-CoA biosynthesis (Drosophila melanogaster)
Fatty acyl-CoA biosynthesis (Gallus gallus)
Fatty acyl-CoA biosynthesis (Mus musculus)
Fatty acyl-CoA biosynthesis (Plasmodium falciparum)
Fatty acyl-CoA biosynthesis (Rattus norvegicus)
Fatty acyl-CoA biosynthesis (Saccharomyces cerevisiae)
Fatty acyl-CoA biosynthesis (Schizosaccharomyces pombe)
Fatty acyl-CoA biosynthesis (Sus scrofa)
Fatty acyl-CoA biosynthesis (Xenopus tropicalis)
Authored
Gopinathrao, G (2003-10-03)
Reviewed
Matthews, L (2024-02-28)
Created
Gopinathrao, G (2003-09-07)
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