Estradiol 17-beta-dehydrogenase 8 (HSD17B8) (Ohno et al. 2008) forms a heterotetramer with carbonyl reductase family member 4 (CBR4) (Chen et al. 2009, Zhang et al. 2005). The heterotetramer has NADPH-dependent 3-ketoacyl-acyl carrier protein reductase activity which is suggested to play a role in biosynthesis of fatty acids in mitochondria (Venkatesan et al. 2014).
Prus, P, Venkatesan, R, Awoniyi, LO, Sah-Teli, SK, Wierenga, RK, Hiltunen, JK, Jiang, G, Chen, Z, Kastaniotis, AJ
Miinalainen, IJ, Hiltunen, JK, Wierenga, RK, Rajaram, V, Kastaniotis, AJ, Chen, Z
Joshi, AK, Hofmann, J, Schweizer, E, Zhang, L, Smith, S
Nakajin, S, Ohno, S, Nishikawa, K, Honda, Y
3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity of 2xHSD17B8:2xCBR4 [mitochondrial matrix]
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