2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP

Stable Identifier
Reaction [transition]
Homo sapiens
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Estradiol 17-beta-dehydrogenase 8 (HSD17B8) (Ohno et al. 2008) forms a heterotetramer with carbonyl reductase family member 4 (CBR4) (Chen et al. 2009, Zhang et al. 2005). The heterotetramer has NADPH-dependent 3-ketoacyl-acyl carrier protein reductase activity which is suggested to play a role in biosynthesis of fatty acids in mitochondria (Venkatesan et al. 2014).
Literature References
PubMed ID Title Journal Year
25203508 Insights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenase

Prus, P, Venkatesan, R, Awoniyi, LO, Sah-Teli, SK, Wierenga, RK, Hiltunen, JK, Jiang, G, Chen, Z, Kastaniotis, AJ

Nat Commun 2014
19571038 17beta-hydroxysteroid dehydrogenase type 8 and carbonyl reductase type 4 assemble as a ketoacyl reductase of human mitochondrial FAS

Miinalainen, IJ, Hiltunen, JK, Wierenga, RK, Rajaram, V, Kastaniotis, AJ, Chen, Z

FASEB J. 2009
15668256 Cloning, expression, and characterization of the human mitochondrial beta-ketoacyl synthase. Complementation of the yeast CEM1 knock-out strain

Joshi, AK, Hofmann, J, Schweizer, E, Zhang, L, Smith, S

J. Biol. Chem. 2005
17978863 Expression in E. coli and tissue distribution of the human homologue of the mouse Ke 6 gene, 17beta-hydroxysteroid dehydrogenase type 8

Nakajin, S, Ohno, S, Nishikawa, K, Honda, Y

Mol. Cell. Biochem. 2008
Catalyst Activity

3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity of 2xHSD17B8:2xCBR4 [mitochondrial matrix]

Orthologous Events
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