Reactome | 2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP

2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP

Stable Identifier

R-HSA-8862152

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

a 3-oxoacyl-(ACP) + H(+) + NADPH => a (3R)-hydroxyacyl-(ACP) + NADP(+)

ReviewStatus

5/5

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2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP

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Estradiol 17-beta-dehydrogenase 8 (HSD17B8) (Ohno et al. 2008) forms a heterotetramer with carbonyl reductase family member 4 (CBR4) (Chen et al. 2009, Zhang et al. 2005). The heterotetramer has NADPH-dependent 3-ketoacyl-acyl carrier protein reductase activity which is suggested to play a role in biosynthesis of fatty acids in mitochondria (Venkatesan et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
25203508	Insights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenase Venkatesan, R, Sah-Teli, SK, Awoniyi, LO, Jiang, G, Prus, P, Kastaniotis, AJ, Hiltunen, JK, Wierenga, RK, Chen, Z	Nat Commun	2014
19571038	17beta-hydroxysteroid dehydrogenase type 8 and carbonyl reductase type 4 assemble as a ketoacyl reductase of human mitochondrial FAS Chen, Z, Kastaniotis, AJ, Miinalainen, IJ, Rajaram, V, Wierenga, RK, Hiltunen, JK	FASEB J.	2009
15668256	Cloning, expression, and characterization of the human mitochondrial beta-ketoacyl synthase. Complementation of the yeast CEM1 knock-out strain Zhang, L, Joshi, AK, Hofmann, J, Schweizer, E, Smith, S	J. Biol. Chem.	2005
17978863	Expression in E. coli and tissue distribution of the human homologue of the mouse Ke 6 gene, 17beta-hydroxysteroid dehydrogenase type 8 Ohno, S, Nishikawa, K, Honda, Y, Nakajin, S	Mol. Cell. Biochem.	2008