SCD desaturates ST-CoA to OLE-CoA

Stable Identifier
R-HSA-5690565
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Acyl-CoA desaturase (SCD), located on the ER membrane, is the terminal enzyme of the liver microsomal stearyl-CoA desaturase system and is the rate-limiting enzyme in the cellular synthesis of monounsaturated fatty acids (MUFAs) from saturated fatty acids. SCD utilises O2 and electrons from reduced ferrocytochrome b5 (Fe(2+)Cb5) to catalyse the insertion of a double bond into a range of fatty acyl-CoA substrates. This example shows stearoyl-CoA (ST-CoA) desaturation to oleoyl-CoA (OLE-CoA) (Li et al. 1994, Zhang et al. 1999). Studies of tagged recombinant enzyme overexpressed in transiently transfected cells suggest that the enzyme forms dimers and higher oligomers (Zhang et al. 2005).

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Catalyst Activity
Title
stearoyl-CoA 9-desaturase activity of SCD dimer [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
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