RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA

Stable Identifier
R-HSA-8957389
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Polycistronic transcripts, where a single mRNA can encode several different polypeptide chains, are common in prokaryotes. In humans, only 3 bicistronic transcripts have been characterised to date. Human cDNAs encoding both RPP14 of the RNase P complex and mitochondrial 3-hydroxyacyl thioester dehydratase (HTD2) have been isolated. HTD2 functions in the mitochondrial fatty acid synthesis (FAS) pathway, dehydrating (3R)-hydroxyacyl-CoA (3HA-CoA) to trans-2-enoyl-CoA (t2E-CoA) (Autio et al. 2008).

Literature References
PubMed ID Title Journal Year
17898086 An ancient genetic link between vertebrate mitochondrial fatty acid synthesis and RNA processing

Autio, KJ, Kastaniotis, AJ, Pospiech, H, Miinalainen, IJ, Schonauer, MS, Dieckmann, CL, Hiltunen, JK

FASEB J. 2008
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Catalyst Activity
Title
3-hydroxyacyl-CoA dehydratase activity of HTD2 [mitochondrial matrix]
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Activity
Orthologous Events
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