Reactome | Conversion of malonyl-CoA and acetyl-CoA to palmitate

Conversion of malonyl-CoA and acetyl-CoA to palmitate

Stable Identifier

R-HSA-75872

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH => a long-chain fatty acid + n CO2 + (n+1) CoA + 2n NADP(+), acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O

ReviewStatus

5/5

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Conversion of malonyl-CoA and acetyl-CoA to palmitate

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Cytosolic fatty acid synthase (FAS) complex catalyzes the reaction of acetyl-CoA with 7 malonyl-CoA and 14 NADHP + 14 H+ to form a molecule of palmitate and 7 CO2, 14 NADP+, 8 CoASH, and 6 H2O. The process proceeds via the successive condensations of malonyl groups onto the growing acyl chain,each followed by loss of CO2 and three steps of reduction (Jayakumar et al. 1995; Smith et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
7567999	Human fatty acid synthase: properties and molecular cloning Jayakumar, A, Wakil, SJ, Huang, WY, Hsu, M, Chirala, SS, al-Feel, W, Abu-Elheiga, L, Tai, MH	Proc Natl Acad Sci U S A	1995
12689621	Structural and functional organization of the animal fatty acid synthase. Joshi, AK, Witkowski, A, Smith, S	Prog Lipid Res	2003