Conversion of malonyl-CoA and acetyl-CoA to palmitate

Stable Identifier
R-HSA-75872
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH => a long-chain fatty acid + n CO2 + (n+1) CoA + 2n NADP(+), acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O
ReviewStatus
5/5
Locations in the PathwayBrowser
General
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Cytosolic fatty acid synthase (FAS) complex catalyzes the reaction of acetyl-CoA with 7 malonyl-CoA and 14 NADHP + 14 H+ to form a molecule of palmitate and 7 CO2, 14 NADP+, 8 CoASH, and 6 H2O. The process proceeds via the successive condensations of malonyl groups onto the growing acyl chain,each followed by loss of CO2 and three steps of reduction (Jayakumar et al. 1995; Smith et al. 2003).
Literature References
PubMed ID Title Journal Year
7567999 Human fatty acid synthase: properties and molecular cloning

Jayakumar, A, Wakil, SJ, Huang, WY, Hsu, M, Chirala, SS, al-Feel, W, Abu-Elheiga, L, Tai, MH

Proc Natl Acad Sci U S A 1995
12689621 Structural and functional organization of the animal fatty acid synthase.

Joshi, AK, Witkowski, A, Smith, S

Prog Lipid Res 2003
Participants
Participates
Catalyst Activity

fatty acid synthase activity of FASN dimer [cytosol]

Orthologous Events
Cross References
RHEA
Authored
Created
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