acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O

Stable Identifier
R-HSA-75872
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Conversion of malonyl-CoA and acetyl-CoA to palmitate
ReviewStatus
5/5
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Cytosolic fatty acid synthase (FAS) complex catalyzes the reaction of acetyl-CoA with 7 malonyl-CoA and 14 NADHP + 14 H+ to form a molecule of palmitate and 7 CO2, 14 NADP+, 8 CoASH, and 6 H2O. The process proceeds via the successive condensations of malonyl groups onto the growing acyl chain,each followed by loss of CO2 and three steps of reduction (Smith et al. 2003).
Literature References
PubMed ID Title Journal Year
12689621 Structural and functional organization of the animal fatty acid synthase.

Joshi, AK, Witkowski, A, Smith, S

Prog Lipid Res 2003
Participants
Participates
Catalyst Activity

fatty acid synthase activity of FASN dimer [cytosol]

Orthologous Events
Authored
Created
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