Reactome | SCD5 desaturates ST-CoA to OLE-CoA

SCD5 desaturates ST-CoA to OLE-CoA

Stable Identifier

R-HSA-8847579

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

Synonyms

2 Fe(II)-(cytochrome b5) + 2 H(+) + O2 + octadecanoyl-CoA => (9Z)-octadecenoyl-CoA + 2 Fe(III)-(cytochrome b5) + 2 H2O

ReviewStatus

5/5

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Stearoyl-CoA desaturase 5 (SCD5, also known as acyl-CoA desaturase 4), located on the ER membrane, utilises O2 and electrons from reduced ferrocytochrome b5 (Fe(2+)Cb5) to catalyse the insertion of a double bond into a range of fatty acyl-CoA substrates. SCD5 is most abundant in brain and pancreas. The reaction annotated here shows stearoyl-CoA (ST-CoA) desaturation to oleoyl-CoA (OLE-CoA). Studies of tagged recombinant enzyme overexpressed in transiently transfected cells suggest that the enzyme forms dimers and higher oligomers (Wang et al. 2005; Zhang et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
15610069	Characterization of human SCD2, an oligomeric desaturase with improved stability and enzyme activity by cross-linking in intact cells Shi, Y, Yang, Y, Zhang, S	Biochem. J.	2005
15907797	Characterization of HSCD5, a novel human stearoyl-CoA desaturase unique to primates Cao, G, Wang, J, Su, C, Yu, L, Huang, X, Schmidt, RE, Gould, K	Biochem. Biophys. Res. Commun.	2005