Formation of fatty acid synthase (FAS) dimer

Stable Identifier
R-HSA-163756
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Formation of fatty acid synthase (FAS) dimer
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Association of cytosolic FAS into multimers is linked to increased catalytic activity (Locke et al. 2008).
Literature References
PubMed ID Title Journal Year
18455495 Differential activation of recombinant human acetyl-CoA carboxylases 1 and 2 by citrate

Locke, GA, Cheng, D, Witmer, MR, Tamura, JK, Haque, T, Carney, RF, Rendina, AR, Marcinkeviciene, J

Arch Biochem Biophys 2008
Participants
Input
Output
Participates
as an event of
Catalyst Activity

fatty acid synthase activity of FASN [cytosol]

Physical Entity
FASN [cytosol] (Homo sapiens)
Activity
fatty acid synthase activity (GO:0004312)
Orthologous Events
Formation of fatty acid synthase (FAS) dimer (Bos taurus)
Formation of fatty acid synthase (FAS) dimer (Caenorhabditis elegans)
Formation of fatty acid synthase (FAS) dimer (Canis familiaris)
Formation of fatty acid synthase (FAS) dimer (Danio rerio)
Formation of fatty acid synthase (FAS) dimer (Dictyostelium discoideum)
Formation of fatty acid synthase (FAS) dimer (Drosophila melanogaster)
Formation of fatty acid synthase (FAS) dimer (Gallus gallus)
Formation of fatty acid synthase (FAS) dimer (Mus musculus)
Formation of fatty acid synthase (FAS) dimer (Rattus norvegicus)
Formation of fatty acid synthase (FAS) dimer (Sus scrofa)
Formation of fatty acid synthase (FAS) dimer (Xenopus tropicalis)
Reviewed
Hill, DP  (2024-04-12)
Created
Gopinathrao, G  (2005-05-06)
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