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Cyclin E associated events during G1/S transition
Stable Identifier
R-HSA-69202
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
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Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
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The transition from the G1 to S phase is controlled by the Cyclin E:Cdk2 complexes. As the Cyclin E:Cdk2 complexes are formed, the Cdk2 is phosphorylated by the Wee1 and Myt1 kinases. This phosphorylation keeps the Cdk2 inactive. In yeast this control is called the cell size checkpoint control. The dephosphorylation of the Cdk2 by Cdc25A activates the Cdk2, and is coordinated with the cells reaching the proper size, and with the DNA synthesis machinery being ready. The Cdk2 then phosphorylates G1/S specific proteins, including proteins required for DNA replication initiation. The beginning of S-phase is marked by the first nucleotide being laid down on the primer during DNA replication at the early-firing origins.Failure to appropriately regulate cyclin E accumulation can lead to accelerated S phase entry, genetic instability, and tumorigenesis. The amount of cyclin E protein in the cell is controlled by ubiquitin-mediated proteolysis (see Woo, 2003).This pathway has not yet been annotated in Reactome.
Participants
Events
Formation of Cyclin E:Cdk2 complexes
(Homo sapiens)
Translocation of Cyclin E:Cdk2 complex to the nucleus
(Homo sapiens)
Translocation of p21 to the nucleus
(Homo sapiens)
Translocation of p27 to the nucleoplasm
(Homo sapiens)
Inactivation of Cyclin E:Cdk2 complexes by p27/p21
(Homo sapiens)
AKT phosphorylates p21Cip1 and p27Kip1
(Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21
(Homo sapiens)
Phosphorylation of Cyclin E:CDK2 complexes by WEE1
(Homo sapiens)
MYC:MAX binds the CDC25A gene
(Homo sapiens)
The CDC25A gene transcription is stimulated by MYC and E2F1 and inhibited by the DREAM complex
(Homo sapiens)
Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A
(Homo sapiens)
CAK-mediated phosphorylation of Cyclin E:Cdk2
(Homo sapiens)
Association of Rb with Cyclin E:Cdk2 complexes
(Homo sapiens)
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
(Homo sapiens)
Participates
as an event of
G1/S Transition (Homo sapiens)
Orthologous Events
Cyclin E associated events during G1/S transition (Bos taurus)
Cyclin E associated events during G1/S transition (Caenorhabditis elegans)
Cyclin E associated events during G1/S transition (Canis familiaris)
Cyclin E associated events during G1/S transition (Danio rerio)
Cyclin E associated events during G1/S transition (Drosophila melanogaster)
Cyclin E associated events during G1/S transition (Gallus gallus)
Cyclin E associated events during G1/S transition (Mus musculus)
Cyclin E associated events during G1/S transition (Rattus norvegicus)
Cyclin E associated events during G1/S transition (Sus scrofa)
Cyclin E associated events during G1/S transition (Xenopus tropicalis)
Cross References
BioModels Database
BIOMD0000000723
,
BIOMD0000000939
,
BIOMD0000000660
,
BIOMD0000000954
,
BIOMD0000000700
,
BIOMD0000000943
Created
Walworth, N (2003-06-05)
O'Donnell, M (2003-06-05)
© 2024
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