During G1, the activity of cyclin-dependent kinases (CDKs) is controlled by the CDK inhibitors (CKIs) CDKN1A (p21) and CDKN1B (p27), thereby preventing premature entry into S phase (see Guardavaccaro and Pagano, 2006). The efficient recognition and ubiquitination of p27 by the SCF (Skp2) complex requires the formation of a trimeric complex containing p27 and cyclin E/A:Cdk2.
Eytan, E, Draetta, GF, Hershko, A, Montagnoli, A, Pagano, M, Carrano, AC, Fiore, F
Keyomarsi, K, Elledge, SJ, Adami, GR, Wei, N, Harper, JW
Liu, X, Nacusi, L, Wang, W, Sheaff, RJ
cyclin-dependent protein serine/threonine kinase inhibitor activity of CDKN1A,CDKN1B [nucleoplasm]
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