Translocation of p27 to the nucleoplasm

Stable Identifier
R-HSA-187506
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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p27 translocates to the nucleoplasm where it associates with CyclinE:Cdk2 complexes. Localization of p27 to the nucleus is necessary to inhibit Cdk activation by Cdk-activating kinase.

Literature References
PubMed ID Title Journal Year
9632134 Cytoplasmic displacement of cyclin E-cdk2 inhibitors p21Cip1 and p27Kip1 in anchorage-independent cells

Orend, G, Hunter, T, Ruoslahti, E

Oncogene 1998
Participants
Participant Of
Orthologous Events
Authored
Created