Reactome | AKT phosphorylates p21Cip1 and p27Kip1

AKT phosphorylates p21Cip1 and p27Kip1

Stable Identifier

R-HSA-198613

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Phosphorylation of p27Kip1 at T157 and of p21Cip1 at T145 by AKT leads to their retention in the cytoplasm, segregating these cyclin-dependent kinase (CDK) inhibitors from cyclin-CDK complexes.

Literature References

PubMed ID	Title	Journal	Year
11231573	Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells Zhou, BP, Liao, Y, Xia, W, Spohn, B, Lee, MH, Hung, MC	Nat. Cell Biol.	2001
12244303	Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer Viglietto, G, Motti, ML, Bruni, P, Melillo, RM, D'Alessio, A, Califano, D, Vinci, F, Chiappetta, G, Tsichlis, P, Bellacosa, A, Fusco, A, Santoro, M	Nat Med	2002