Reactome | AKT phosphorylates p21Cip1 and p27Kip1

AKT phosphorylates p21Cip1 and p27Kip1

Stable Identifier

R-HSA-198613

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

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Phosphorylation of p27Kip1 at T157 and of p21Cip1 at T145 by AKT leads to their retention in the cytoplasm, segregating these cyclin-dependent kinase (CDK) inhibitors from cyclin-CDK complexes.

Literature References

PubMed ID	Title	Journal	Year
12244303	Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer Viglietto, G, Motti, ML, Bruni, P, Melillo, RM, D'Alessio, A, Califano, D, Vinci, F, Chiappetta, G, Tsichlis, P, Bellacosa, A, Fusco, A, Santoro, M	Nat Med	2002
11231573	Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells Zhou, BP, Liao, Y, Xia, W, Spohn, B, Lee, MH, Hung, MC	Nat. Cell Biol.	2001